左旋卡尼汀治疗慢性肺心病急性加重期患者疗效观察

目的:评价左旋卡尼汀对慢性肺心病急性加重期患者的疗效。方法:126例随机分成两组。对照组60例,用吸氧、抗感染、祛痰、平喘、利尿等常规治疗;治疗组66例,在常规治疗基础上加用左旋卡尼汀3.0静脉点滴,每日1次,14 d为一疗程。结果:治疗组临床总有效率(89.4%)明显优于对照组(65.0%)(P<0.01);两组动脉血气、心脏指数、射血分数及右室内径均显著改善(P<0.01),治疗组改善更为显著(P<0.01)。结论:左旋卡尼汀治疗慢性肺心病急性加重期患者是有效的。

Effects of levocarnitine in treating patients with acute exacerbation of chronic pulmonary heart disease

AIM: To evaluate the efficacy of levocarnitine in treating patients with acute exacerbation of chronic pulmonary heart disease.METHODS: 126 patients were divided into two groups randomly:60 patients in control group were treated with conventional therapy for inhalling oxygen,controlling infection,relieving asthma,expelling phlegm and diuresis;66 patients in test group were treated with 3 g/d levocarnitine,i.v.drip for 14 days in addition to conventional therapy.RESULTS: The total effective rate in test group was superior to that of control group(P<0.01).The arterial blood gases,cardiac index,ejection fraction and right ventricular internal diameter were improved significantly(P<0.01) in two groups.The test group was remarkably improved compared with control group after treatment(P<0.01).CONCLUSION: Levocarnitine is effective in treating patients with acute exacerbation of chronic pulmonary heart disease.