Philosophy of treatment and the role of chemotherapy in paediatric soft tissue sarcomas |
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| Affiliation: | 1. Department of Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, The Netherlands;2. Groupe d’Etude de la Thrombose de Bretagne Occidentale, Equipe d’Accueil 3878, Department of Internal Medicine and Chest Diseases, Brest, France;3. Centre d’Investigation Clinique INSERM 1412, Groupe d’Investigation et de Recherche Clinique, Brittany University of Brest, Brest, France;1. The Kirby Institute, UNSW Sydney, Sydney, Australia;2. The Centre for Social Research in Health, UNSW Sydney, Sydney, Australia;1. Discipline of Paediatrics, School of Women''s and Children''s Health, University of New South Wales, Sydney, NSW 2052, Australia;2. Department of Nutrition and Dietetics, Sydney Children''s Hospital, High Street, Randwick, NSW 2031, Australia;3. University of Wollongong, Northfields Avenue, Wollongong, NSW 2522, Australia;4. School of Health Sciences and Priority Research Centre in Physical Activity and Nutrition, Faculty of Health and Medicine, University of Newcastle, University Drive, Callaghan, NSW 2308, Australia;5. miCF Research Centre and Department of Gastroenterology, Sydney Children''s Hospital, High Street, Randwick, NSW 2031, Australia |
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| Abstract: | ![]()
Although overall survival rates for children with soft tissue sarcoma have improved, progress for some sub-groups of patients has been less encouraging than might be expected. Priorities for the future include the better identification of patients who can be cured with minimal therapy and better treatment for those who have a poor outcome with current therapy. Improved understanding of the biology of this group of tumours may provide opportunities to utilise some of the more recently designed novel forms of therapy aimed at molecular targets. Although considerable amounts of valuable clinical data have been acquired through clinical trials in patients with RMS, further efforts to systematically explore therapy in children with non-RMS soft tissue sarcoma are now required and there are opportunities for adult-paediatric collaboration in designing new approaches to therapy. |
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