瓜蒌化学成分的分离与鉴定

目的对葫芦科栝楼属植物栝楼果实瓜蒌体积分数为90%的乙醇提取物的正丁醇萃取部分进行化学成分研究。方法利用硅胶、反相中低压、凝胶Sephadex LH-20柱色谱以及制备型高效液相色谱等手段进行分离纯化,并通过理化性质和各种波谱数据对这些化合物进行结构鉴定。结果从瓜蒌的正丁醇萃取部位分离得到4个化合物,分别鉴定为2,5-二羟甲基呋喃(furan-2,5-diyldim-ethanol,1)、柯伊利素-7-O-β-D-葡萄糖苷(chrysoerid-7-O-β-D-glucoside,2)、苹果酸丁二酯(dibutyl-2-hydroxysuccinate,3)、(2,2'-Bioxazolidine)-3,3'-diethanol(4)。结论这4个化合物均为首次从该属植物中分离得到,其中化合物4是新天然产物。

Isolation and identification of constituents from fruit of Trichosanthes kirilowii Maxim.

Objective To isolate and identify the chemical constituents of the butanol extract part of the fruit of Trichosanthes kirilowii Maxim.ethanol extract. Methods The chemical constituents of T kirilowii Maxim.were studied by multiple chromatographical techniques(such as silica gel chromatography,Sephadex LH-20,prepretion HPLC,and etc.)and these compounds were identified by analysis of the spectral data and chemical properties. Results On the basis of physio-chemical evidence and spectral analysis,the structure...