蛋白酪氨酸激酶抑制剂的研究进展

目的综述蛋白酪氨酸激酶(protein tyrosine kinase,PTK)抑制剂类抗肿瘤药物的研究进展。方法根据已报道的PTK抑制剂的相关文献,将其分为国外已经上市、国外处于临床研究和我国自主研发的PTK抑制剂进行具体介绍。结果 PTK在细胞内的信号转导中起着重要的作用,与肿瘤细胞的生长、增殖、分化和凋亡密切相关,目前已经有多种结构的PTK抑制剂类抗肿瘤药物上市或进入临床研究。结论随着PTK的作用机制及构效关系研究的不断深入,该类药物终将成为治疗肿瘤的有效药物。

Progress on the research of the protein tyrosine kinase inhibitors

Objective To review the recent developments in the research of antitumor agents of protein tyrosine kinase(PTK)inhibitors. Methods According to references about PTK inhibitors,the compounds were introduced from three areas:drug approved by FDA,in clinical studies and independently researched by Chinese. Results PTK played significant role on the cell signal transduction pathway and was closely related to tumor cell growth,proliferation,differentiation and apoptosis.Many PTK inhibitors had been revealed to be potent on tumors and approved by FDA. Conclusions The article will provide references for the further research of PTK inhibitors.