| 共调控共互作蛋白结构域的特征研究 |
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| 引用本文： | 刘永宾,高磊,李冬果,李霞. 共调控共互作蛋白结构域的特征研究[J]. 中国优生与遗传杂志, 2010, 0(3): 18-21 |
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| 作者姓名： | 刘永宾 高磊 李冬果 李霞 |
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| 作者单位： | 首都医科大学生物医学工程学院;哈尔滨医科大学生物信息科学与技术学院; |
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| 基金项目： | 国家自然基金(批准号:30871394、30370798、30571034); 国家863项目(批准号:2007AA02Z329); 黑龙江科技攻关项目(批准号:ZJG0501、1055HG009、GB03C602-4、BMFH060044) |
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| 摘 要： | 目的研究在共调控蛋白、共互作蛋白、及同时存在共调控与共互作关系的蛋白中所包含结构域的分布特征。方法利用转录调控数据、蛋白互作数据和蛋白结构域数据,以聚集系数为测度,研究结构域在共调控集合、共互作集合以及共调控且共互作的集合中的聚集特征,并通过随机实验验证聚集特征的显著性。结果共调控集合、共互作集合以及共调控且共互作集合的聚集系数显著较高,具有显著性（P〈0．01）。结论研究表明,共调控集合、共互作集合、共调控且共互作集合更倾向于含有相同的结构域。
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| 关 键 词： | 共调控 共互作 结构域特征 聚集系数 |
Research on domain features combinate of co-regulation and co-interaction. |
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| LIU Yong-bin,GAO Lei,LI Dong-guo,LI Xia,.. Research on domain features combinate of co-regulation and co-interaction.[J]. Chinese Journal of Birth Health & Heredity, 2010, 0(3): 18-21 |
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| Authors: | LIU Yong-bin GAO Lei LI Dong-guo LI Xia . |
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| Affiliation: | LIU Yong-bin1,GAO Lei1,LI Dong-guo1,LI Xia1,2.(1.Biomedical Engineering College of Capital Medical University,Beijing 100069,2.College of Bioinformatics Science , Technology,Harbin Medical University,Harbin 150081) |
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| Abstract: | Objective:Reserch on the distributing features of domains which are included in the proteins set,the proteins set are co-regulate,co-interaction or co-regulate and co-interaction.Methods:The characteristics of domain in co-regulation protein set,co-interaction protein set and co-regulation & co-interacton protein set are evaluated by aggregation factor,and verify significant of the aggregation factor through random experiment.Results:Aggregation factors are significance(P<0.01) in the co-regulation dataset,... |
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| Keywords: | Co-regulation Co-interaction Domain features Aggregation factor |
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