注意缺陷多动障碍儿童执行功能与多价不饱和脂肪酸的相关性分析

目的 探讨注意缺陷多动障碍(ADHD)儿童与正常儿童的执行功能差异,及其与红细胞膜多不饱和脂肪酸(PUFAs)的关联程度.方法 以符合DSM-Ⅳ诊断标准的7～12岁ADHD儿童为病例组(29例),22例正常儿童为对照组.采用韦氏记忆量表(倒背和顺背数字测验)和连线测验评估2组儿童执行功能中的工作记忆和任务管理能力,同时分别取2组儿童外周静脉血3 ml进行外周血红细胞膜(RBC)脂肪酸水平测定.结果 (1)病例组完成划线测验B式所用的时间(s)较对照组长[(118.26±40.79)s,(95.55±28.25)s,P <0.05],倒背、顺背得分及总分较正常对照组低( P <0.05);(2)病例组的血红细胞膜饱和脂肪酸18:0水平高于正常对照组,n-3族不饱和脂肪酸中EPA、22:5(n-3)、DHA水平低于正常对照组,总n-6族和总n-3族不饱和脂肪酸n-6%、n-3%均低于正常对照组( P <0.05).(3)划线测验B式所需时间与22:5(n-3)呈负相关( r =-0.288, P <0.05);听觉工作记忆测验中顺背得分与22:5(n-3) 、DHA、 n-3%呈正相关( r =0.313～0.379, P <0.05),与n-6/n-3呈负相关( r =-0.369, P <0.01);听觉工作记忆测验总分与22:5(n-3) 、DHA、 n-3%呈正相关( r =0.305～0.374, P <0.05),与n-6/n-3呈负相关( r =-0.320, P <0.05).结论 (1)ADHD儿童听觉工作记忆和任务管理存在损害;(2)ADHD儿童RBC膜的某些不饱和脂肪酸水平低于正常儿童;(3)ADHD儿童听觉工作记忆和任务管理等执行功能与不饱和脂肪酸之间存在相关性.

The corralation of executive function and red blood cell polyunsaturated fatty acids in children with attention deficit hyperactivity disorder in

Objective To discuss difference of executive function (EF) in children with attention deficit/hyperactivity disorder (ADHD) in China and the correlation degree of EF and polyunsaturated fatty acid (PUFAs).Methods 22 children with ADHD were classified according to the Fourth Edition of Diagnostic and Statistic Manual of Mental Disorder (DSM-Ⅳ) criteria, with age range of 6～12 years were involved in the study. 29 health children(HC) were matched by age as control. The two groups were examined using Wechsler memory scale(digits down-reciting and reversal reciting) and Tail making test (TMT, A&B) to evaluate intelligence, the capacity of auditory short-term memory and working memory, complicated mission management. At the same time, in knowing the facts agreeing to fetch vein blood for 3 ml in two sets of children down respectively,and determine the thickness of fatty acids in the red than HC (118.26±40.79,95.55±28.25,P <0.05). The scores of digits reciting (train reciting, reversal reciting and the total scores) was lower in ADHD The scores of digits reciting (train reciting) was positively correlated correlated with n-6/n-3( r =-0.369,P <0.01). The scores of digits reciting n-3%( r =0.305～0.374, P <0.05),and was negatively correlated with children such as working memory and complicated mission management were correlated with the executive function of ADHD children such as working memory and complicated mission management.