长秀霖联合拜糖平和门冬胰岛素治疗口服降糖药疗效不佳的老年2型糖尿病的临床观察

目的观察长秀霖联合拜糖平和门冬胰岛素对治疗老年T2DM患者血糖、HbA1c变化、低血糖发生率及临床意义。方法将118例口服降糖药物疗效较差的老年T2DM患者随机分为长秀霖加拜糖平组和门冬胰岛素组。长秀霖组每晚睡前皮下注射1次加三餐前口服拜糖平，门冬胰岛素组早晚餐前各皮下注射1次，共13周，比较两组患者空腹血糖（FBG）及餐后2小时血糖（2hBG）、血脂、HbA1C下降情况，C肽（C-P）水平上升情况，低血糖发生率。结果两组治疗前后血糖、血脂、HbA1C下降明显，C-P上升明显（P〈0．05）；治疗后两组之间对比无显著差异；低血糖反应长秀霖组明显低于门冬胰岛素组（P〈0．01）。结论长秀霖组和门冬胰岛素组都具有明显降低FBG、2hBG、血脂、HbA1c的作用，均明显提高C-P水平。低血糖的发生率长秀霖组明显低于门冬胰岛素组。

The observation of efficacy of basalin combined with glucobay versus insulin aspart treatment in old T2DM patients poorly controlled by oral hypoglycemic drugs

Objective To investigate the effect of basalin combined nith glucobay versus insulin aspart on changes of blood glucose, HbA1 c, incidence of hypoglycemia in elderly patients with T2DM. Methods 118 old T2DM patients poorly controlled with oral hypoglycemic drugs were randomly divided into basalin combined with glucobay group and insulin aspart group. Basalin was injected before sleep and glucobay was taken before meals; insulin aspart group was injected before morning and evening meals for total 13 weaks. We compared fasting and 2-hour postprandial blood glucose and lipids, the decrement of HbA1c, the increment of C peptide and the incidence of hypoglycemia between two groups. Results The two groups showed significant decrements of blood glucose, lipid, HbA1 c and the increment of C peptide （P〈0. 05） after treatment, with no significant difference （P〉0. 05） between the two groups. Incidence of hypoglycemia was significantly lower in basalin group than in insulin aspart group（P〈0. 01）. Conclusions The basalin group versus insulin aspart group has the similar improvement of fasting glucose and 2 hours postprandial glucose, HbAlc and lipids and C peptide （all P〈0. 05）. The incidence of hypoglycemia is significantly lower in basalin group than in insulin aspart group.