A parallel increase in placental oxidative stress and antioxidant defenses occurs in pre-gestational type 1 but not gestational diabetes |
| |
| Authors: | J.R. Araú jo,C. Ramalho,A. Correia-Branco,A. Faria,T. Ferraz,E. Keating,F. Martel |
| |
| Affiliation: | 1. Department of Biochemistry (U38-FCT), Faculty of Medicine, University of Porto, 4200-319 Porto, Portugal;2. Department of Obstetrics and Gynaecology, Centro Hospitalar S. João, 4200-319 Porto, Portugal;3. Chemistry Investigation Centre (CIQ), Department of Chemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal |
| |
| Abstract: | ![]()
We aimed to determine the oxidative stress status in placentas obtained from gestational (GDM) and type 1 (T1D) diabetic pregnancies. Malonaldehyde and protein carbonyls, two biomarkers of oxidative damage, were higher in T1D but not in GDM placentas. Also, higher reduced glutathione and lower oxidized glutathione levels and higher glutathione peroxidase activity were found in T1D but not in GDM placentas. These results suggest that T1D placentas may develop a protective antioxidant mechanism to overcome higher oxidative stress levels. |
| |
| Keywords: | Maternal diabetes Oxidative stress Placenta |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
