Global real-time quantitative reverse transcription-polymerase chain reaction detecting proto-oncogenes associated with 14q32 chromosomal translocation as a valuable marker for predicting survival in multiple myeloma |
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| Authors: | Atsushi Inagaki Emi Tajima Miyuki Uranishi Haruhito Totani Yu Asao Hiroka Ogura Ayako Masaki Tatsuya Yoshida Fumiko Mori Asahi Ito Hiroki Yano Masaki Ri Satoshi Kayukawa Takae Kataoka Shigeru Kusumoto Takashi Ishida Yoshihito Hayami Ichiro Hanamura Hirokazu Komatsu Hiroshi Inagaki Yasufumi Matsuda Ryuzo Ueda Shinsuke Iida |
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| Affiliation: | 1. Department of Medical Oncology and Immunology, Nagoya City University Graduate School of Medical Sciences, Nagoya City, Japan;2. Department of Hematology, Kainan Hospital, Yatomi City, Japan;3. Department of Medical Oncology, Nagoya Memorial Hospital, Nagoya City, Japan;4. Department of Hematology, Aichi Medical University, Nagakute City, Japan;5. Department of Anatomic Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Sciences, Nagoya City, Japan;6. Technology Development, Section 1, Research & Development Department, SRL Inc., Hino-city, Japan |
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| Abstract: | ![]()
CCND1, FGFR3 and c-MAF mRNA expression of tumor samples from 123 multiple myeloma patients were analyzed by global RQ/RT-PCR. CCND1, FGFR3 and c-MAF were positive in 44 (36%), 28 (23%) and 16 (13%) of patients, respectively. In 7 patients, both FGFR3 and c-MAF were positive. The expression of c-MAF was independent unfavorable prognostic factors for overall survival (OS). Autologous stem cell transplantation improved progression-free survival of CCND1-positive patients. Bortezomib, thalidomide or lenalidomide extended OS of FGFR3 and/or c-MAF-positive patients. Thus, CCND1, FGFR3 and c-MAF mRNA expression can predict survival and is useful for planning stratified treatment strategies for myeloma patients. |
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| Keywords: | Multiple myeloma CCND1 FGFR3 C-MAF Survival FISH PCR |
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