| 依那西普治疗非全身型幼年特发性关节炎的近期疗效及安全性观察 |
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| 引用本文： | 李亚琴,曹兰芳,薛海燕. 依那西普治疗非全身型幼年特发性关节炎的近期疗效及安全性观察[J]. 临床儿科杂志, 2011, 29(1). DOI: 10.3969/j.issn.1000-3606.2011.01.008 |
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| 作者姓名： | 李亚琴 曹兰芳 薛海燕 |
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| 作者单位： | 上海交通大学医学院附属仁济医院儿科,上海,200001 |
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| 摘 要： | 目的观察依那西普治疗非全身型幼年特发性关节炎的疗效和安全性。方法对30例非全身型幼年特发性关节炎患儿皮下注射依那西普0.4 mg/(kg.次),每周2次,在治疗后1周、1个月及3个月采用ACRPedi 30/50/70评分进行疗效评估。结果治疗后1周、1月及3月时ACR Pedi 30达标率分别为16.70%、90.00%、96.67%,ACR Pedi 50达标率分别为3.30%、30.00%、66.70%,ACR Pedi 70达标率分别为0、0、16.70%(5),且无重大不良事件发生。结论依那西普治疗非全身型幼年特发性关节炎具有较好的近期疗效,在病程早期使用效果更显著,不良反应小且发生率低。
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| 关 键 词： | 依那西普 幼年特发性关节炎 疗效 不良反应 |
The observation of short-term efficacy and safety of etanercept in treatment of non-systemic juvenile idiopathic arthritis |
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| LI Ya-qin,CAO Lan-fang,XUE Hai-yan. The observation of short-term efficacy and safety of etanercept in treatment of non-systemic juvenile idiopathic arthritis[J]. The Journal of Clinical Pediatrics, 2011, 29(1). DOI: 10.3969/j.issn.1000-3606.2011.01.008 |
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| Authors: | LI Ya-qin CAO Lan-fang XUE Hai-yan |
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| Affiliation: | LI Ya-qin,CAO Lan-fang,XUE Hai-yan(Department of Pediatrics,Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai 200001,China) |
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| Abstract: | Objective To observe the short-term clinical efficacy and safety of etanercept in treatment of non-systemic juvenile idiopathic arthritis(JIA).Methods Thirty patients with non-systemic JIA were subcutaneously injected with etanercept 0.4 mg/kg twice a week.Clinical efficacy was evaluated based on ACR pedi 30/50/70 score 1 week,1 month,3 months after treatment.Results One week,1 month and 3 months after treatment,the ACR Pedi 30 compliance rates were 16.70%(5),90.00%(27)and 96.67%(29),ACR Pedi 50 compliance ... |
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| Keywords: | etanercept juvenile idiopathic arthritis clinical efficacy adverse effects |
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