原发性小肠非霍奇金淋巴瘤的临床诊治分析

目的 探讨原发性小肠非霍奇金淋巴瘤的临床特点及诊治方法.方法 收集我院1999年1月至2009年12月所收治的58例原发性小肠非霍奇金淋巴瘤患者的临床资料,回顾性分析其临床特点和治疗方式对患者生存期的影响.结果 患者全部为I期和Ⅱ期原发性小肠非霍奇金淋巴瘤患者,腹痛为患者最常见的临床症状(63.8%),末端回肠及回盲部(87.9%)为其最好发部位.本组患者总的5年生存率52.8%;I期患者的5年生存率为62.5%,Ⅱ期患者的5年生存率为46.7%,两者差异有统计学意义(P=0.023).单纯手术治疗组患者5年生存率27.2%,手术治疗加化疗组患者5年生存率59.6%,两者生存率差异有统计学意义(P=0.004).结论 对于原发性小肠非霍奇金淋巴瘤,应首选手术结合化疗、放疗的综合治疗.

Clinical analysis of primary small intestinal non-hodgkin lymphoma

Objective To explore the clinical characteristic,diagnosis and treatment regimens of primary small intestinal non-Hodgkin lymphoma.Methods Data of 58 small intestinal non-Hodgkin lymphoma patients treated from January,1999 to December,2009 was collected and analyzed.Results Abdominal pain is the common symptom of primary small intestinal non-Hodgkin lymphoma.All the patients were stage I and stage Ⅱ.The distal ileum and ileocecal junction are the most predilection site.The overall 5-year survival rate is 52.8%,and it is 62.5% and 46.7% for I-stage and Ⅱ-stage patients respectively with significant statistics difference(P=0.023). The 5-year survival is 27.2% for patients receiving operation alone,and 58.6%for patients receiving operation plus chemotherapy and or radiotherapy,which has significant statistics difference(P=0.004).Conclusions Treatment of primary small intestinal non-Hodgkin lymphoma should prefer the therapy based on surgery with combination of chemotherapy and radiotherapy.