北京市区某工厂职工及家属1982名脊柱关节病的流行病学调查

背景未分化脊柱关节病命名的提出为强直性脊柱炎和其他脊柱关节病的早期诊断提供了线索,并避免了错误的治疗.目的了解北京市区某工厂某厂16岁以上职工及家属脊柱关节病患病情况、人类组织相容性复合体B27及骶髂关节X射线平片检查结果.设计整群抽样调查.单位汕头市澄海区人民医院内科和汕头大学医学院风湿病学研究室及北京朝阳医院内科.对象于1999-05/10对北京市区某厂16岁以上职工及家属1 982名进行调查,其中男1 025名,女957名.均对调查项目知情同意,并积极配合.方法用修订的中国-国际抗风湿联盟风湿病调查表,对调查对象挨户逐人询问,阳性者进行体检,疑似者行类风湿因子、人类组织相容性复合体B27和X射线平片检查.主要观察指标被调查人群16岁以上职工及家属脊柱关节病患病情况、人类组织相容性复合体B27及骶髂关节X射线平片检查结果.结果纳入对象1 982名均进入结果分析.脊柱关节病构成比1.61%(32/1 982),其中强直性脊柱炎构成比0.31%(6/1982),未分化脊柱关节病构成比1.21%(24/1982),银屑病性关节炎构成比0.10%(2/1982),未发现其他脊柱关节病.未分化脊柱关节病主要症状为炎症性腰痛和非对称性关节炎[83%(20/24),62%(15/24)],类风湿因子均为阴性,25%(6/24)人类组织相容性复合体B27阳性,男女比例1.21.结论脊柱关节病在北京地区发病构成比为1.61%,其主要构成为强直性脊柱炎和未分化脊柱关节病.

Epidemiological study on spondyloarthropathy in 1 982 workers and their relatives residing in Beijing urban district

BACKGROUND: The nomination of undifferentiated spondyloarthropathy (USpA) has provided clues for the early diagnosis of spondylitis ankylopoietica and other subsets of SpA, thereby avoiding possible wrong treatments.OBJECTIVE: To investigate the prevalence of SpA in the workers and their adult relatives aged over 16 years old from a factory in Beijing urban district, as well as the results of human major histocompatibility complex (MHC) B27 and X-ray inspection on sacroiliac joint.DESIGN: Systematic sampling investigation.SETTING: Department of Internal Medicine, Chenghai District People's Hospital of Shantou City; Rheumatism Research Institute, Medical College of Shantou University; Department of Internal Medicine, Beijing Chaoyang Hospital.PARTICIPANTS: A survey was conducted among 1982 workers and their adult relatives aged over 16 years from a factory in Beijing urban district between May and October 1999; there were 1,025 males and 957 females.They all volunteered into this study after informed of the experiment.METHODS: All examinees were surveyed door to door with the modified Chinese-International Anti-rheumatic Alliance Rheumatism Questionnaire,those with positive results were subjected to physical examination and those suspicious cases were subjected to MHC-B27 and X-ray examination.MAIN OUTCOME MEASURES: The prevalence of SpA in the workersand their adult relatives aged over 16 years from a factory in Beijing urban district, as well as the results of MHC-B27 and sacroiliac joint X-ray inspection.RESULTS: Totally 1,982 subjects were enrolled in this study and all entered the result analysis. The prevalence of spondyloarthropathy was 1.61%(32/1 982), amongst which the prevalence of ankylopoietic spondylitis,USpA, and psoriastic arthritis was 0.31% (6/1 982), 1.21% (24/1 982),and 0.10% (2/1 982), respectively. No other subsets of SpA were observed. USpA was mainly presented by inflammatory lumbago and asymmetric arthrosteitis [83% (20/24), 62% (15/24)], while rheumatoid factor was negative in all subjects. Meanwhile, MHC-B27 was proved positive in 25% (6/24) subjects with the male-to-female ratio of 1.2:1.CONCLUSION: The prevalence of SpA is 1.61% in Beijing urban area,and SpA mainly consists of ankylopoietic spondylitis and USpA.