脑缺血中Bcl-2对自噬与凋亡的双重调控机制

脑缺血是一种高死亡率、高致残率的神经退行性疾病。脑缺血发病时,自噬与凋亡是缺血半暗带区神经元的主要死亡方式,减轻缺血半暗带区脑组织损伤和改善神经元症状是治疗脑缺血的重要措施。B淋巴细胞瘤-2基因(B-cell lymphoma-2,Bcl-2)不但是最经典的抗凋亡基因,而且与细胞的自噬通路密切相关。Bcl-2可以双重调控自噬与凋亡的信号通路,从而影响脑缺血后神经元的存活。该文分析了脑缺血与细胞自噬及凋亡的关系,并综述了Bcl-2介导的自噬与凋亡对脑缺血的作用及其双重调控机制,以期为中医药防治脑缺血研究提供新的靶点以及理论依据。

Dual Regulation Mechanism of Bcl-2 on Autophagy and Apoptosis in Cerebral Ischemia

Cerebral ischemia is a n euro degenerative disease with high mortality and high disability.During the development of cerebral ischemia,autophagy and apoptosis play critical roles in cell death of neurons in the ischemic penumbra.Alleviating brain tissue damage in the ischemic penumbra and improving neuronal symptoms are important measures for the treatment of cerebral ischemia.B-cell lymphoma-2(Bcl-2)is not only the most classical anti-apoptotic gene,but also a critical factor that closely related to the autophagy pathway of cells.Bcl-2 process dual regulation on autophagy and apoptosis,which affect the degree of neurons damage caused by cerebral ischemia.Therefore,this paper aimed to analyze the relationship between cerebral ischemia and autophagy/apoptosis,and summarized the double regulative effects of Bcl-2 mediating autophagy and apoptosis on cerebral ischemia,to provide a new research direction for the prevention and treatment of cerebral ischemia using Chinese medicine.