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| 水通道蛋白1在矽肺大鼠肺组织中的表达及意义初探 | |
| 引用本文： | 张丽,郝小惠,王宏丽,赵金垣,刘和亮. 水通道蛋白1在矽肺大鼠肺组织中的表达及意义初探[J]. 中国工业医学杂志, 2012, 25(2): 91-93+161 |
| 作者姓名： | 张丽 郝小惠 王宏丽 赵金垣 刘和亮 |
| 作者单位： | 河北联合大学公共卫生学院;河北联合大学医学实验研究中心;北京大学第三医院职业病研究中心 |
| 基金项目： | 河北省科学技术研究与发展计划项目(项目编号:092761100D);河北省人事厅留学回国人员择优资助项目(冀人办2008-199) |
| 摘 要： | 目的探讨水通道蛋白1(AQP1)在矽肺肺组织中的表达及意义。方法采用免疫组织化学、免疫荧光、Western blot等方法检测矽肺模型大鼠肺组织AQP1分布及表达。结果正常对照组和生理盐水组大鼠肺组织中AQP1表达差异无统计学意义,矽肺模型大鼠肺组织中AQP1表达较正常对照组和生理盐水组减低。结论矽肺模型大鼠肺组织中AQP1表达降低,提示AQP1可能在矽肺的发病过程中具有一定的作用。 |
| 关 键 词： | 二氧化硅 矽肺 水通道蛋白1 |
Expression and significance of aquaporin 1 in lung tissue of silicotic rats |
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| ZHANG Li,HAO Xiao-hui,WANG Hong-li,ZHAO Jin-yuan,LIU He-liang. Expression and significance of aquaporin 1 in lung tissue of silicotic rats[J]. Chinese Journal of Industrial Medicine, 2012, 25(2): 91-93+161 | |
| Authors: | ZHANG Li HAO Xiao-hui WANG Hong-li ZHAO Jin-yuan LIU He-liang |
| Affiliation: | (Public Health School,Hebei United Uni versity,Tangshan 063000,China) |
| Abstract: | Objective To explore the expres sion and the significance of aquaporin 1(AQP1)in lung tissue of silicotic rats.M ethods Immunohistochemistry,immunofluore scence,and Western blot were used to det ect distribution and expression of AQP1 in lung tissue of rats exposed to silica.Results The expression of AQP1 in normal and the saline control rats had no significant difference.The expression of AQP1 in silicotic model rats’ lung decreased compare with that of the normal an d the saline control rats.Conclusion Th e expression of AQP1 decreased in silico tic rats,which suggest that AQP1 may pla y an important role in the formation of silicosis. |
| Keywords: | silicon dioxide silicosis aqua porin 1 |
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