排毒养生胶囊治疗海洛因依赖的研究

目的观察中药排毒养生胶囊对海洛因依赖临床脱毒的治疗效果。方法将海洛因依赖患者580例随机分为2组,治疗组302例应用排毒养生胶囊、对照组278例应用美沙酮,采用阿片类药物依赖戒断症状量表(OWS)、焦虑量表(HAMA)评定疗效。结果治疗1~4d,治疗组戒断症状完全控制率>80%,治疗5 d以后完全控制率达100%;总控制水平稍低于对照组,但2组之间无显著性差异(P>0.05)。结论中药排毒养生胶囊对海洛因成瘾临床脱毒治疗效果较满意,与常规戒毒药物美沙酮疗效相近,且临床接受率和依从性好,使用安全。

Study of Paidu-Yangsheng capsule on heroin dependence

Objective It is to observe the detoxicating effect of traditional Chinese medicine Paidu-Yangsheng capsule on heroin dependence.Methods 580 patients with heroin dependence were randomly divided into two groups.302 cases were in treatment group and given Paidu-Yangsheng capsule,and 278 cases were in control group and given Methadone.The curative effect was evaluated using OWS and HAMA.Results The complete control rate of abstinence syndrome in treatment group after one to four days' treatment was > 80% and that was 100% after five days' treatment.The total control level in treatment group was a little lower than that in control group,but there was no significant difference(P>0.05).Conclusion Paidu-Yangsheng capsule has a satisfactory detoxicating effect on heroin dependence which was similar with the normal detoxicating drug Methadone,and its clinical accepting rate,compliance and safety are good.