| 红曲中洛伐他汀总量的测定方法 |
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| 引用本文： | 罗仁才,孙开奇,谢申猛,韩英,赵妍平. 红曲中洛伐他汀总量的测定方法[J]. 卫生研究, 2003, 32(2): 157-158 |
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| 作者姓名： | 罗仁才 孙开奇 谢申猛 韩英 赵妍平 |
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| 作者单位： | 北京市疾病预防控制中心,北京,100013 |
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| 摘 要： | 考察降脂红曲产品的安全性和功效性 ,测定洛伐他汀的总量比仅仅测定其内酯含量更为可取。本文建立了测定红曲中洛伐他汀总量的方法 ,并对方法的可行性进行了验证。采用HPLC方法 ,色谱柱 :C18柱(2 5 0mm× 4 60mm) ;流动相 :甲醇 :水 (72 :2 8) ,检测波长 :2 3 8nm ;流速 :1 0ml min;柱温 :室温 ,方法回收率98 3 % ,RSD =0 3 3 %。
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| 关 键 词： | 红曲 洛伐他汀 高效液相色谱法 |
| 文章编号： | 1000-8020(2003)02-0157-02 |
| 修稿时间： | 2002-07-19 |
Determination of total lovastatin in red rice |
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| Luo Rencai,Sun Kaiqi,Xie Shenmeng,Han Ying,et al.. Determination of total lovastatin in red rice[J]. Journal of hygiene research, 2003, 32(2): 157-158 |
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| Authors: | Luo Rencai Sun Kaiqi Xie Shenmeng Han Ying et al. |
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| Affiliation: | Beijing Center for Disease Control and Prevention, Beijing 100013, China. |
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| Abstract: | In order to text effectiveness and safety of red rice products, the determination of total lovastatin is more optional than that of determination of its lactone only. The method for determination of total lovastatin is established in this study. HPLC method is applied with the C18 column (250 mm x 4.60 mm). Flow phase: water (72:28); wave length: 238 nm; Flow speed: 1.0 ml/min; column temperature: room temperature. Moreover, the reliability of this method validated recovery rate 98.3, RSD = 0.33%. |
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| Keywords: | red rice lovastatin HPLC |
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