烧伤后瘢痕局部应用辣椒素治疗的初步临床观察

目的　观察局部外用辣椒素对增生性瘢痕的治疗效果。　方法　采用随机、双盲、自身对照法。治疗组瘢痕表面涂抹 0 .0 5 %的辣椒素霜 ,对照组涂抹不含辣椒素的霜剂 ,3次 d,使用 6周。观察用药前后的瘙痒情况和药物不良反应 ,并采用常规病理、免疫组化和胶原纤维染色等方法观察辣椒素的止痒作用以及对瘢痕增生的影响。　结果　辣椒素具有明显的止痒作用 ,其作用与P物质的减少有关 ,但用药后两组在瘢痕的色泽、软硬度、厚度及胶原纤维的形态分布上 ,未见有明显差异。　结论　辣椒素可用于增生性瘢痕的止痒 ,效果好 ,无明显不良反应 ,但其抑制瘢痕增生的作用不显著。

A preliminary report of therapeutic effects of topical capsaicin in postburn hypertrophic scar

Objective To observe the therapeutic effects of capsaicin on hypertrophic scar (HS). Methods 12 patients with hypertrophic scar within 3 months were randomly selected for a double-blind study. Each patient received two treatments, 0.05% capsaicin cream for one area of HS, cream vehicle for adjacent HS. The scores of pruritus and side effects of capsaicin were evaluated. Skin biopsies were collected, routine pathological examination, immunohistochemical staining for substance P and special staining for collagen fiber were also performed. Results Capsaicin definitely has an anti-pruritus effect on HS, which is correlated with the decline of content of substance P in scar tissue. The color, texture, thickness of hypertrophic scar and distribution of collagen fiber in HS tissue seemed to be similar between two groups. Conclusion Capsaicin is a good anti-pruritus drug for HS with no severe side effect, but it does not inhibit hypertrophy of scars.