| 胸腺肽α1对老年重症医院获得性肺炎患者免疫功能的影响 |
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| 引用本文： | 王卫,全胜麟,李莹. 胸腺肽α1对老年重症医院获得性肺炎患者免疫功能的影响[J]. 中国医院药学杂志, 2011, 0(17) |
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| 作者姓名： | 王卫 全胜麟 李莹 |
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| 作者单位： | 云南省第一人民医院昆明医学院附属昆华医院; |
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| 摘 要： | 目的:探讨胸腺肽α1治疗对老年重症医院获得性肺炎(SHAP)患者细胞免疫功能的影响及其临床意义。方法:48例SHAP患者随机分为治疗组和对照组。治疗组在对照组基础上给予胸腺肽α1 1.6 mg皮下注射,qd,持续1周,之后改为1.6 mg,皮下注射,隔日一次,共2周。结果:治疗组治疗后单核细胞人类白细胞抗原(HLA-DR)、自然杀伤(NK)细胞、CD4+细胞及CD4+/CD8+比值明显上升;治疗组住院死亡率明显低于对照组,其存活者抗生素应用时间亦比对照组明显缩短。结论:胸腺肽α1能提高SHAP患者免疫功能,有利于感染控制,并降低住院死亡率。
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| 关 键 词： | 胸腺肽α1 老年 重症医院获得性肺炎 免疫功能 |
The influence of thymosin alpha 1 on immune function of elder patients with severe hospital acquired pneumonia |
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| WANG Wei,QUAN Sheng-lin,LI Yin. The influence of thymosin alpha 1 on immune function of elder patients with severe hospital acquired pneumonia[J]. Chinese Journal of Hospital Pharmacy, 2011, 0(17) |
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| Authors: | WANG Wei QUAN Sheng-lin LI Yin |
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| Affiliation: | WANG Wei,QUAN Sheng-lin,LI Yin (The First People's Hospital of Yunnan Provice,Yunnan Kunming 650032,China) |
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| Abstract: | OBJECTIVE To investigate the influence of thymosin alpha 1 on immune function and the clinical significance in elder patients with severe hospital acquired pneumonia(SHAP). METHODS A total of 48 elder patients with SHAP were randomly divided into 2 groups: the treatment group(n=24) and the control group(n=24).The treatment group received 1.6 mg of thymosin alpha1 through subcutaneous injection qd for a week,then received 1.6 mg of thymosin alpha1 through subcutaneous injection every other day for two weeks;... |
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| Keywords: | thymosin alpha 1 elder severe hospital acquired pneumonia immune function |
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