| 老年心衰患者口服地高辛群体药动学模型的建立 |
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| 引用本文： | 陈荣,夏宗玲.老年心衰患者口服地高辛群体药动学模型的建立[J].中国医院药学杂志,2011(12). |
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| 作者姓名： | 陈荣 夏宗玲 |
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| 作者单位： | 常州市第一人民医院; |
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| 摘 要： | 目的:应用非线性混合效应模型计算国人老年心衰患者口服地高辛(digxion)群体药动学参数,以促进个体化给药。方法:采用荧光偏振免疫法(FPIA)测定84例老年患者120例次地高辛的血清浓度并收集相关临床指标,运用NONMEM软件建立群体药动学模型。结果:地高辛的药动学符合一室线性开放模型,固定效应参数中,体质量、剂量、血肌酐及尿素氮对参数有影响。最终回归模型中地高辛血药浓度估算值与实测浓度间线性关系良好。结论:用群体药动学模型分析常规监测数据可为老年患者个体化给药提供依据。
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| 关 键 词： | 地高辛 群体药动学 NONMEM |
Population pharmacokinetics of oral digoxin in elderly CHF patients |
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| CHEN Rong,XIA Zhong-ling.Population pharmacokinetics of oral digoxin in elderly CHF patients[J].Chinese Journal of Hospital Pharmacy,2011(12). |
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| Authors: | CHEN Rong XIA Zhong-ling |
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| Institution: | CHEN Rong,XIA Zhong-ling (Department of Pharmacy,The First Hospital of Changzhou,Jiangsu Changzhou 213003,China) |
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| Abstract: | OBJECTIVE To access the population pharmacokinetic parameters and analyze the characteristics of pharmacokinetics of digoxin given by oral route in elderly heart failure patients using a nonlinear mixed effect model program.METHODS A total of 120 blood samples of digoxin which were collected form 84 elderly patients were analyzed by FPIA.Population pharmacokinetic parameters were assessed and the characteristic of the pharmacokinetic profile was analyzed by using NONMEM program.RESULTS The pharmacokinetic p... |
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| Keywords: | digoxin population pharmacokinetics NONMEM |
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