| 阿苯达唑自微乳释药系统在大鼠体内组织分布 |
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| 引用本文： | 魏丽红,张永军,朱雅婷,曲湘云,李雪芹. 阿苯达唑自微乳释药系统在大鼠体内组织分布[J]. 中国医院药学杂志, 2011, 0(16) |
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| 作者姓名： | 魏丽红 张永军 朱雅婷 曲湘云 李雪芹 |
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| 作者单位： | 石河子大学药学院;石河子大学第一附属医院;华中科技大学同济医学院药学院; |
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| 摘 要： | 目的:通过高效液相色谱法,对大鼠口服阿苯达唑(ABZ)自微乳后组织分布作初步的研究。方法:高效液相色谱法,以阿苯达唑原料药和市售片剂做对照,对口服阿苯达唑自微乳浓缩液进行大鼠体内组织分布研究,考察不同制剂体内的药物分布是否有显著性差异。结果:组织匀浆液浓度测定方法的回收率均大于70%,日内、日间精密度均小于12%;自微乳在大鼠体内分布较广,与原料药及片剂相比,各组织均有不同程度的增加,其中在体内药物浓度分布趋势为肝>肺>肠>脾>肾>胃>脑。结论:与原料药和片剂比较,ABZ-SMEDDS体内分布迅速,组织分布广泛,促进了药物口服吸收,改变了ABZ在体内的组织分布。
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| 关 键 词： | 阿苯达唑 自微乳化释药系统 组织分布 |
Tissue distribution of self-microemulsifying drug delivery system of albendazole in rats |
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| WEI Li-hong,ZHANG Yong-jun,,ZHU Ya-ting,QU Xiang-yun,LI Xue-qin. Tissue distribution of self-microemulsifying drug delivery system of albendazole in rats[J]. Chinese Journal of Hospital Pharmacy, 2011, 0(16) |
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| Authors: | WEI Li-hong ZHANG Yong-jun ZHU Ya-ting QU Xiang-yun LI Xue-qin |
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| Affiliation: | WEI Li-hong1,ZHANG Yong-jun2,3,ZHU Ya-ting1,QU Xiang-yun1,LI Xue-qin1(1.Pharmacy School of Shihezi University,Xinjiang Shihezi 832002,China,2.The First Affiliated Hospital of Shihezi University,3.Tongji School of Pharmacy,Huazhong University of Science and Technology,Hubei Wuhan 430030,China) |
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| Abstract: | OBJECTIVE To investigate the pharmacokinetics and tissue distribution of albendazole microemulsion in rats after oral administration by HPLC method.METHODS An HPLC method was developed for the assay of albendazole,the conventional tablet and the pharmaceutical crude drug were taken as the control.The rats' plasma drug concentrations and its metabolites after double doses oral administration of ABZ-SMEDDS were determined by HPLC.RESULTS The recovery was over 70%;the intra-day and inter-day RSD were less than... |
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| Keywords: | albendazole self-microemulsifying drug delivery system tissue distribution |
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