麦滋林联合奥美拉唑、阿莫西林、克拉霉素治疗消化性溃疡临床疗效观察

目的：观察麦滋林联合奥美拉唑、阿莫西林、克拉霉素治疗消化性溃疡的疗效。方法：选择2008年9月至2010年9月在乌兰察布市中心医院学习期间经电子胃镜确诊为消化性溃疡（包括胃溃疡和十二指肠溃疡）且快速尿素酶试验阳性的患者158例,随机分为治疗组（80例）和对照组（78例）,两组均口服奥美拉唑20 mg/次,2次/d;阿莫西林1.0g/次,2次/d;克拉霉素0.5 g/次,2次/d;治疗组加麦滋林0.67 g/次,3次/d。正规治疗14 d,4周后复查电子胃镜和快速尿素酶试验。根据消化性溃疡电镜分期及尿素酶试验结果判断疗效。结果：治疗组总有效率97.50%,对照组总有效率80.77%,差异有显著性（P〈0.05）。结论：麦滋林联合奥美拉唑、阿莫西林、克拉霉素治疗消化性溃疡获得较好的效果和较高的幽门螺杆旋杆菌（Hp）清除率,是一种安全有效的治疗方法。

Clinical Observation of The Combined Use of Marzulene, Omeprazole, Amoxicillin and Clarithromycin for Treatment of Peptic Ulcer

Objective:To observe the effect of combined use of Marzulene,Omeprazole,Amoxicillin and Clarithromycin in treatment of peptic ulcer.Methods:The 158 patients diagnosed as peptic ulcer(including GU and DU) with gastroscope and the rapid urease test Hp positive were randomly divided into two groups in local center hospital from Sep.2008 to Sep.2010.Omeprazole 20 mg + Amoxicillinand 1.0 g+ clarithromycin 0.5 g two times a day for 14 days were taken in two groups.Then 80 patients in treatment group added with Marzulene 0.67 g,three times a day for 14 days.Results:The total effectiveness of treatment group was 97.50%,the control group was 80.77%.The difference was significant(P<0.05).Conclusion:Treatment of peptic ulcer with Marzulene combined with Omeprazole,Amoxicillin,Clarithromycin get better result and higher Hp clearance rate,can yet be regarded as a safe and effective treatment.