糖尿病2型患者干眼症发病相关因素分析

目的:探讨多种眼表因素异常在糖尿病患者干眼症发病中的作用。方法:50例2型糖尿病患者存在的干眼症状及有关的眼表因素(角膜上皮完整性、泪液基础分泌、泪膜稳定性、结膜上皮鳞状化生程度、杯状细胞密度)检查结果量化后进行单因素及多因素的非条件Logistic回归分析。结果:泪液基础分泌量减少(P=0.012,OR=6.792),泪膜稳定性下降(P=0.043,OR=4.713),结膜杯状细胞密度下降(P=0.024,OR=0.400)与糖尿病患者干眼症发生呈显著正相关,差异有统计学意义。结论:泪膜稳定性下降、泪液基础分泌量减少及杯状细胞密度下降在2型糖尿病患者干眼症的发病中起一定作用。

Analysis of the pathogeny of dry eye in type 2 diabetic patients

·AIM:To explore the relationship between multivariate ocular factors and the development of dry eye in type 2 diabetes mellitus.·METHODS:Fifty cases with type 2 diabetes mellitus were selected and evaluated with the staining with fluorescein sodium on cornea and the tears ferning,a series of ocular testing of the Schirmer I,the tears film stability,the grade of squamous metaplasia,the goblet cell density.A questionnaire about dry eye was surveyed One-way and multivariate non-conditional logistic regres-sion analysis were used to analyze the relation between multivariate ocular factors and the development of dry eye in type 2 diabetes mellitus.·RESULTS:The decrease of basal tears secretion(P=0.012,OR=6.792),the unstable tears flilm(P=0.043,OR=4.713)and lower goblet cell density(P=0.024,OR=0.400)had positive relationship with the development of dry eye in type 2 diabetes mellitus.·CONCLUSION:Our data shows that the unstable tear flilm,the decrease of basal tears secretion and lower goblet cell density might play a role in the development of dry eye in type 2 diabetes mellitus.·