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Efficacy of temozolomide combined with capecitabine (CAPTEM) on refractory prolactinomas as assessed using an ex vivo 3D spheroid assay |
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| Authors: | Ishida Atsushi Shichi Hiroki Fukuoka Hidenori Inoshita Naoko Ogawa Wataru Yamada Shozo |
| Affiliation: | 1.Department of Neurosurgery, Moriyama Memorial Hospital, 134-0081, Tokyo, Japan ;2.Division of Diabetes and Endocrinology, Kobe University Graduate School of Medicine, 650-0017, Kobe, Japan ;3.Division of Diabetes and Endocrinology, Kobe University Hospital, 7-5-2 Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan ;4.Department of Pathology, Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology, 173-0015, Tokyo, Japan ;5.Hypothalamic & Pituitary Center, Moriyama Neurological Center Hospital, 134-0088, Tokyo, Japan ; |
| Abstract: | Pituitary - Refractory prolactinomas resistant to dopamine agonists (DAs) pose a clinical challenge. Temozolomide (TMZ) is a recommended treatment option, but its effects are difficult to predict,... |
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