氟比洛芬酯注射剂用于肺癌手术后自控镇痛的疗效观察

目的观察氟比洛芬酯注射剂用于肺癌手术后自控镇痛的临床疗效。方法选取我院胸外科肺癌患者88例，随机分为对照组（使用芬太尼镇痛，n=42）和研究组（使用氟比洛芬酯镇痛，n=46），观察2组患者术后0、6、12、24、48h的血压、心率、血氧饱和度、视觉模拟评分（VAS）、Ramsay镇静评分（RSS）、自控镇痛按压次数以及不良反应的发生率。结果2组患者的血压、心率、血氧饱和度、VAS、RSS和自控镇痛按压次数等相比差异均无统计学意义，而不良反应中的恶心呕吐在对照组中发生率有31．0％，显著高于研究组的17．4％（P〈0．05）。结论氟比洛芬酯注射剂用于肺癌手术后镇痛疗效良好，不良反应轻。

Observation of effect of flurbiprofen axetil injection for patient-controlled analgesia after lung cancer operation

AIM To observe the efficacy of flurbiprofen METHODS A total of 88 lung caner patients in our hospital analgesia, n = 42） and study group （using flurbiprofen axetil axetil injection for analgesia after lung cancer operation. were randomly divided into control group （using fentanyl analgesia, n = 46）. The blood pressure, heart rate, oxyhemoglobin saturation, visual analogue scale （VAS）, Ramsay sedation scale（RSS） 0, 6, 12, 24 or 48 h after surgery, number of pressing the patient-control machine in 48 h and incidence of adverse drug reactions in 2 groups were determined. RESULTS Blood pressure, heart rate, oxyhemoglobin saturation, VAS, RSS and number of pressing in 2 groups showed no statistical significance, and the nausea and vomiting adverse reaction in control group was 31.0 %, significantly higher than 17.4 % in study group （ P 〈 0.05）. CONCLUSION Flurbiprofen axetil injection produces effectire curative effect with little adverse drug reactions in lung cancer post-operative analgesia