臭氧水联合臭氧油治疗足癣的疗效

目的：观察臭氧水联合臭氧油治疗足癣的临床疗效和不良反应。方法：60例确诊为足癣的患者随机被分为对照组和臭氧组。对照组患者足癣用自来水清洗后用萘替芬酮康唑软膏外涂，每日1次；臭氧组患者足癣用臭氧水清洗后外涂臭氧油，每日1次；均治疗4周。在治疗第1，2和4周结束时，分别采集临床评分数据评价患者病情的改善情况；并在治疗前、治疗第4周末进行真菌镜检，评估真菌感染的情况。结果：治疗4周后，真菌镜检结果显示臭氧组1例阳性，对照组6例阳性，两组间真菌镜检阳性率比较差异无统计学意义(P>0.05)。第1，2，4周的临床评分比较显示不同时间点两组治疗效果差异无统计学意义(P>0.05)。结论：臭氧水联合臭氧油外用治疗足癣有效，且无不良反应。

Efficacy of combination of ozonated water with oil for treatment of tinea pedis

Objective: To evaluate effi cacy of combined therapy with ozonated water and oil on patients withtinea pedis.Methods: A total of 60 patients with tinea pedis were divided into 2 groups in a randomizedand blinded test. Patients in a control group were treated with naftinfine hydrochloride andketoconazole cream once a day. Patients in an ozone group were treated with ozonated water bathand then ozonated oil topical application once a day. Patients in the 2 groups were treated for 4weeks. Clinical and laboratory data were collected for both groups at the end of the 1st week, the2nd week, and the 4th week. The Pearson chi-square was performed to compare scores of theclinical signs and symptoms (CSS) and the mycological result between the 2 groups. Independentsamples T-test was performed to compare the curative eff ect between the 2 groups.Results: After 4 weeks’ treatment, 6 patients were positive in the control group determined bymycological examination while 1 patient was positive in the ozone group, with no significantdiff erence between the 2 groups (P>0.05). Changes in CSS at the end of the 1st week, 2nd week,and 4th week were obtained and showed no signifi cant diff erence between the 2 groups at the 3diff erent time points (P>0.05). No side eff ects were observed.Conclusion: Combination of ozonated water with oil is eff ective on treatment of tinea pedis and itshows no side eff ects.