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Change and significance of osteocalcin in children with Kawasaki disease

??Objective To observe the change of different forms of osteocalcin in children with Kawasaki disease??KD?? and explore the relationship of osteocalcin with Kawasaki Disease. Methods A total of 34 hospitalized children with Kawasaki disease between March 2015 and December 2015 were selected??and all of them came from Children’s Hospital of Shanxi Province. According to the course??each child was divided into acute stage and subacute stage. At the same time??20 healthy children were chosen as the control. The levels of plasma N-MID osteocalcin and undercarboxylated osteocalcin were measured. Erythrocyte sedimentation rate??ESR?? and C-reactive protein??CRP?? were analyzed and the changes of osteocalcin??ESR and CRP were compared. Results The levels of plasma undercarboxylated osteocalcin in KD patients were significantly lower than control???14.2±0.3?? ng/mL for acute stage????14.4±0.3?? μg/L for subacute stage????16.3±0.4?? μg/L for control??P??0.01????. The levels of plasma N-MID osteocalcin in KD patients did not differ from control???27.3±0.5?? μg/L for acute stage????27.5±0.5?? μg/L for subacute stage????28.3±0.8?? μg/L for control??all P??0.05????. The levels of CRP in acute stage were significantly higher than in subacute stage???79.1±10.3??mg/L for acute stage vs.??2.7±0.5?? mg/L for subacute stage??P??0.001????. The levels of ESR in acute stage were higher than in subacute stage???58.5±4.1?? mm/h for acute stage vs. ??49.1±4.7?? mm/h for subacute stage??P??0.05????. In acute stage?? the correlation analysis showed that the levels of plasma undercarboxylated osteocalcin were negatively correlated with CRP and ESR??P??0.05??. Conclusion Plasma undercarboxylated osteocalcin might participate in the pathogenesis and development of KD. The measurement of plasma undercarboxylated osteocalcin could be valuable in the diagnosis of KD in children.