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| 骨代谢生化指标临床应用专家共识（2019） | |
| 引用本文： | 张萌萌﹟ 张秀珍﹟ 邓伟民﹟ 张智海﹟ 徐辉﹟ 葛继荣﹟ 王永福﹟ 黄宏兴﹟ 史晓林﹟ 张东伟﹟ 毛未贤﹟ 马倩倩﹟ 高远﹟ 郭郡浩 张红红 张晓梅 印平 赵方 晁爱军 张岩 李英华 李毅中 赵国阳 董红宇 吴岩 吴涤 邹军 周惠琼. 骨代谢生化指标临床应用专家共识（2019）[J]. 中国骨质疏松杂志, 2019, 0(10): 1357-1372 |
| 作者姓名： | 张萌萌﹟ 张秀珍﹟ 邓伟民﹟ 张智海﹟ 徐辉﹟ 葛继荣﹟ 王永福﹟ 黄宏兴﹟ 史晓林﹟ 张东伟﹟ 毛未贤﹟ 马倩倩﹟ 高远﹟ 郭郡浩 张红红 张晓梅 印平 赵方 晁爱军 张岩 李英华 李毅中 赵国阳 董红宇 吴岩 吴涤 邹军 周惠琼 |
| 作者单位： | 1.《中国骨质疏松杂志》社，北京 1001022.同济大学附属同济医院，上海 2000653.中国人民解放军南部战区总医院，广东 广州 5100104.航空总医院，北京 1000125.吉林大学，吉林 长春 1300126.福建省中医药研究院，福建 福州 3500037.内蒙古科技大学包头医学院第一附属医院， 内蒙古 包头 0140108.广州中医药大学第三附属医院，广东 广州 5102409.浙江中医药大学附属第二医院，浙江 杭州 31000510.北京中医药大学糖尿病研究中心，北京 10002911.吉林省一汽总医院，吉林 长春 13001112.中国人民解放军东部战区总医院，江苏 南京 21000213.解放军总医院，北京 10085314.北京大学国际医院，北京 10220615.大连医科大学附属金山医院，辽宁 本溪 11700016.辽宁省金秋医院，辽宁 沈阳 11001617.天津医院，天津 30021118.上海中医药大学附属龙华医院，上海 20000319.上海市第五人民医院，上海 20024020.福建医科大学附属第二医院，福建 泉州 36200021.江苏大学附属医院，江苏 镇江 21200022.首都医科大学北京市石景山医院，北京 10004323.内蒙古医科大学，内蒙古 呼和浩特 01011024.内蒙古科技大学包头医学院，内蒙古 包头 01404025.上海体育学院，上海 20043826.中国人民解放军总医院第四医学中心，北京 100037 |
| 摘 要： | 骨代谢生化指标包括钙磷代谢调节指标、骨形成标志物、骨吸收标志物、激素与细胞因子。骨代谢生化指标分别来源于骨、软骨、软组织、皮肤、肝、肾、小肠、血液及内分泌腺体等,是由成骨细胞或破骨细胞分泌的酶和激素,以及骨基质的胶原蛋白代谢产物或非胶原蛋白。骨代谢生化指标可及时反映骨转换状态,灵敏度高、特异性强,用于骨质疏松诊断分型、预测骨折风险、抗骨质疏松治疗疗效评价,以及代谢性骨病的鉴别诊断。并且在骨质疏松流行病学、发病机制、骨质疏松药物的研究方面具有重要的临床意义。 |
| 关 键 词： | 骨代谢；钙磷代谢调节指标；骨形成标志物；激素；细胞因子； |
Expert consensus on clinical application of biochemical indicators of bone metabolism (2019) |
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| Affiliation: | 1.Chinese Journal of Osteoporosis,Beijing 1001022.Tong Ji Hospital affiliated Tongji University,Shanghai 2000653.General Hospital of Southern Theater of the COMMAND, Guangzhou 5100104.Aviation General Hospital, Beijing 1000125.Jilin University, Changchun,Jilin 1300126.Fujian Academy of Chinese Medicine, Fuzhou, Fujian 3500037.The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia 0140108.The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 5102409.The Second Affiliated Hospital of Zhejiang University of Chinese Medicine, Hangzhou 31000510.Diabetes Research Center, Beijing University of Chinese Medicine, Beijing 10002911.FAW General Hospital of Jilin Province, Changchun,Jilin 130011,12.General Hospital of Eastern Theater of the COMMAND, Nanjing, Jiangsu 21000213.PLA General Hospital, Beijing 10085314.Peking University International Hospital, Beijing 10220615.Jinshan Hospital Affiliated to Dalian Medical University, Benxi ,Liaoning 11700016.Jinqiu Hospital of Liaoning Province, Shenyang ,Liaoning 11001617.Tianjin Hospital, Tianjin 30021118.Longhua Hospital Affiliated to Shanghai University of Chinese Medicine, Shanghai 20000319.The fifth People''s Hospital of Shanghai, Shanghai 20024020.The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian 36200021. Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 21200022.Shijingshan Hospital, Capital Medical University, Beijing 10004323.Inner Mongolia Medical University, Inner Mongolia, Hohhot 01011024.Baotou Medical College, Inner Mongolia University of Science and Technology, Inner Mongolia Baotou 01404025.Shanghai University of Sport, Shanghai 20043826.The Fourth Medical Center of General Hospital of the Chinese People''s Liberation Army, Beijing 100037,China |
| Abstract: | The bone metabolism biochemical markers included calcium and phosphorus metabolism indicators, bone formation markers, bone resorption markers, hormone and cytokine. The bone metabolism biochemical markers were derived from the bone, cartilage, soft tissue, skin, liver, kidney, small intestine, blood, endocrine glands, and so on. They were enzymes and hormones secreted by osteoblasts or osteoclasts, and the product or non-collagen proteins of metabolic bone collagen matrix. The bone metabolism biochemical markers could reflect the state of bone turnover promptly, with high sensitivity and specificity, it had been used in osteoporosis diagnosis, prediction of fracture risk, curative effect observation of drug treatment, and the differential diagnosis of metabolic bone disease. And it had important clinical significance in epidemiology, pathogenesis and drug research of osteoporosis. |
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