表达Brg/Brm相关因子53a的脑胶质瘤的磁共振影像学特征

目的：探讨脑胶质瘤Brg/Brm相关因子53a(Brg/Brm associated factor 53a,BAF53a)表达的磁共振(magnetic resonance imaging,MRI)影像学特征。方法：根据免疫组织化学检测结果,将121例脑胶质瘤患者分为BAF53a高表达组(n=79)和低表达组(n=42),分析病灶位置、数目、边界、最大直径、周围水肿、中线结构移位、均质性、囊变坏死、出血、强化程度、室管膜强化、软脑膜强化、深部白质受侵、肿瘤跨越中线共14项影像学特征。结果：病灶边界、病灶水肿程度、病灶强化程度、深部白质受侵在BAF53a高表达组和低表达组中差异具有统计学意义(均P<0.05)。 结论：在常规MRI中显示的肿瘤边界、周围水肿程度、强化程度以及深部白质受侵情况有助于判断脑胶质瘤BAF53a的基因状态。

Magnetic resonance imaging features of glioma with Brg/Brm associated factor 53a expression

Objective: To explore the magnetic resonance imaging (MRI) characteristics of glioma with Brg/Brm-associated factor 53a (BAF53a) expression. Methods: A total of 121 patients with glioma was divided into a BAF53a high expression group (n=79) and a low expression group (n=42) according to the results of immunohistochemistry. Then the MRI characteristics, including lesion location, number, boundary, maximum diameter, peripheral edema, midline structure shift, homogeneity, cystic necrosis, hemorrhage, strengthening degree, ependymal strengthening, pia mater enhancement, deep white matter invasion and lesion across the midline (total 14 items), were analyzed. Results: The results showed that there were significance difference in lesion border, lesion edema, enhancement of the lesion, and deep white matter invasion between the 2 groups (all P<0.05). Conclusion: The MRI characteristics, such as lesion border, lesion edema degree, enhancement degree of the lesion and deep white matter invasion, might be associated with BAF53a expression in gliomas.