| TP53缺失的初诊多发性骨髓瘤伴颅内侵犯2例 |
| |
| 引用本文： | 曲双,廖丽昇,谢颖,郑志海,陈碧云. TP53缺失的初诊多发性骨髓瘤伴颅内侵犯2例[J]. 中南大学学报(医学版), 2018, 43(11): 1272-1275. DOI: 10.11817/j.issn.1672-7347.2018.11.018 |
| |
| 作者姓名： | 曲双 廖丽昇 谢颖 郑志海 陈碧云 |
| |
| 作者单位： | 福建医科大学附属省立临床医学院,福建省立医院血液科,福州 350001 |
| |
| 基金项目： | 福建省自然科学基金(2015J05140);福建省中青年骨干人才培养项目(2016-ZQN-11);福建省立医院优秀青年医师项目(2014061)。 |
| |
| 摘 要： | 两例初治多发性骨髓瘤伴颅内侵犯的患者起病均以中枢神经系统功能受损为临床表现,颅骨受到破坏的同时存在多发硬膜侵犯。伴TP53缺失的遗传学异常与颅内侵犯的相关性,尚无定论。患者均接受含硼替佐米、阿霉素的多药联合方案,取得良好的短期疗效,与文献报道符合。TP53缺失的初治多发性骨髓瘤伴颅内侵犯预后不良。以硼替佐米为基础的强化学药物治疗方案联合自体或异基因造血干细胞移植有望提高临床疗效。
|
| 关 键 词： | 骨髓瘤 TP53 颅内侵犯 |
Intracranial involvement in newly diagnosed multiple myeloma with TP53 deletion: Two case reports |
| |
| QU Shuang,LIAO Lisheng,XIE Ying,ZHENG Zhihai,CHEN Biyun. Intracranial involvement in newly diagnosed multiple myeloma with TP53 deletion: Two case reports[J]. Journal of Central South University. Medical sciences, 2018, 43(11): 1272-1275. DOI: 10.11817/j.issn.1672-7347.2018.11.018 |
| |
| Authors: | QU Shuang LIAO Lisheng XIE Ying ZHENG Zhihai CHEN Biyun |
| |
| Affiliation: | Department of Hematology, Fujian Provincial Hospital; Provincial Clinical Medicine College, Fujian Medical University, Fuzhou 350001, China |
| |
| Abstract: | We report two rare cases of multiple myeloma (MM) with dural intracranial disease and TP53deletion. Th e two patients presented with skull lytic lesion and dural involvement of myeloma. Th eassociation between intracranial involvement in MM and TP53 deletion has not been determined.Th e two patients received bortezomib-based intensive induction and got good response, just as thatreported in literature. MM presenting with dural intracranial disease and TP53 deletion at diagnosisis associated with poor outcome. Multi-drug regime containing bortezomib followed by autologousor allogeneic stem cell transportation would improve the prognosis. |
| |
| Keywords: | myeloma TP53 intracranial involvement |
|
| 点击此处可从《中南大学学报(医学版)》浏览原始摘要信息 |
|
点击此处可从《中南大学学报(医学版)》下载全文 |
