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| PARP-1/AIF介导的细胞凋亡 | |
| 引用本文： | 赵增强,徐勤枝. PARP-1/AIF介导的细胞凋亡[J]. 医学分子生物学杂志, 2007, 4(2): 140-142 |
| 作者姓名： | 赵增强 徐勤枝 |
| 作者单位： | 军事医学科学院放射与辐射医学研究所,北京市,100850;军事医学科学院放射与辐射医学研究所,北京市,100850 |
| 基金项目： | 国家高技术研究发展计划(863计划) |
| 摘 要： | PARP-1/AIF通路介导的非caspase依赖性细胞凋亡多见于缺血再灌注或某些药物引起的神经细胞死亡。PARP-1定位于细胞核,参与细胞内多种生理活动。广泛的DNA损伤引起PARP-1过度激活,进而使线粒体蛋白AIF转位至细胞核,作为DNA内切酶引发染色质凝集、DNA片段化和细胞死亡。最近,对该通路信号转导和调控机制的研究取得了快速的进展。 |
| 关 键 词： | 凋亡 多聚(腺苷二磷酸-核糖)聚合酶1 凋亡诱导因子 |
| 修稿时间： | 2006-10-24 |
PARP-1/AIF-Mediated Apoptosis |
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| ZHAO Zengqiang,XU Qinzhi. PARP-1/AIF-Mediated Apoptosis[J]. Journal of Medical Molecular Biology, 2007, 4(2): 140-142 | |
| Authors: | ZHAO Zengqiang XU Qinzhi |
| Abstract: | PARP-1/AIF-mediated caspase-independent apoptosis plays an important role in ischemia/reperfusion or drug-induced death of neural cells. PARP-1 is located in nucleus and participates in various physiological processes. Extensive DNA damage causes overactivation of PARP-1 which induces, in turn, the translocation of AIF from mitochondria to nucleus where AIF functions as a DNA endonuclease, leading to chromatin condensation, DNA fragmentation and apoptosis. Recently, rapid progress has been made in the study of the molecular mechanism of signal transduction and regulation. |
| Keywords: | apoptosis poly(ADP-ribose)-polymerase 1 apotosis-inducing factor |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |