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| 环境内分泌干扰物对胚胎发育调控基因DNA甲基化的影响 | |
| 引用本文： | 赵岩. 环境内分泌干扰物对胚胎发育调控基因DNA甲基化的影响[J]. 复旦学报(医学版), 2011, 38(6): 560-564. DOI: 10.3969/j.issn.16728467.2011.06.020 |
| 作者姓名： | 赵岩 |
| 作者单位： | 复旦大学公共卫生安全教育部重点实验室 上海200032 |
| 基金项目： | 上海市自然基金项目(10ZR1402000); 国家自然科学基金项目(30500397,81072263) |
| 摘 要： | DNA甲基化(DNA methylation)是一种重要的遗传修饰,是表观遗传学研究的重要内容。许多研究证实环境内分泌干扰物能够影响DNA甲基化的水平，有关环境内分泌干扰物对DNA甲基化的影响已经成为当前胚胎发育学的研究热点。本文就环境内分泌干扰物（environmental endocrine disruptor,EED）对胚胎发育调控基因DNA甲基化的影响进行综述,为今后的机制性研究提供参考。 |
| 关 键 词： | 环境内分泌干扰物 DNA甲基化 胚胎发育 |
Effect of environmental endocrine disruptors on DNA methylation of embryonic developmental regulating gene |
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| ZHAO Yan. Effect of environmental endocrine disruptors on DNA methylation of embryonic developmental regulating gene[J]. Fudan University Journal of Medical Sciences, 2011, 38(6): 560-564. DOI: 10.3969/j.issn.16728467.2011.06.020 | |
| Authors: | ZHAO Yan |
| Affiliation: | Key Laboratory of Public Heath Safety, Ministry of Education Fudan University, Shanghai 200032, China |
| Abstract: | DNA methylation is an important genetic modification and an important part of epigenetics.Many studies have confirmed that environmental endocrine disruptors can affect the level of DNA methylation.The effect of environmental disruptors on DNA methylation has become the research focus of embryonic development.In order to provide reference for future mechanism study,we reviewed the effect of environmental endocrine disruptors(EED) on DNA methylation of embryonic developmental regulating gene. |
| Keywords: | environmental endocrine disruptor DNA methylation embryonic development |
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