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参附注射液对急性左心功能不全患者心功能及血浆脑钠肽的影响
引用本文:张志林,温玉梅.参附注射液对急性左心功能不全患者心功能及血浆脑钠肽的影响[J].长春中医药大学学报,2016,32(3):504-505.
作者姓名:张志林  温玉梅
作者单位:张家口市第二医院,河北 张家口,075000;张家口市第二医院,河北 张家口,075000
基金项目:河北省张家口市科技计划项目(0801043D)。
摘    要:目的:探讨参附注射液对急性左心功能不全(AHF)患者心功能及血浆脑钠肽(BNP)的影响。方法分析我院60例 AHF 患者临床资料,随机分为观察组和对照组,各30例。2组给予相应吸氧、卧床休息、低盐饮食;速尿20 mg /次,1次/ d 静脉推注;硝酸甘油10 mg 加0.9%氯化钠注射液250 mL 持续泵入,1次/ d;地高辛0.125 mg /次,1次/ d。观察组在此基础上加用参附注射液60 mL 加0.9%氯化钠注射液250 mL 静脉滴注,1次/ d。2组疗程均为7 d,疗程结束后采用化学发光免疫法检测治疗前后血浆 BNP 水平,超声心动图测定左室舒张末内径(LVEDD),计算左室射血分数(LVEF),采用 Guyatt 进行6 min 步行实验(6MWT),测定6 min 最大步行距离。结果治疗后 BNP 水平明显降低,观察组优于对照组,有统计学意义(P <0.05);治疗后 LVEDD明显减小,LVEF、6MWT 明显增加,观察组优于对照组,有统计学意义(P <0.05)。结论参附注射液可提高左心室收缩功能,能有效降低血浆 BNP 水平,改善心脏功能。

关 键 词:参附注射液  急性左心功能不全  心功能  血浆脑钠肽

Shenfu injection on cardiac function and brain natriuretic peptide in patients with acute left heart failure
ZHANG Zhilin,WEN Yumei.Shenfu injection on cardiac function and brain natriuretic peptide in patients with acute left heart failure[J].Journal of Changchun College of Traditional Chinese Medicine,2016,32(3):504-505.
Authors:ZHANG Zhilin  WEN Yumei
Abstract:Objective To explore the effect of Shenfu injection on the cardiac function and brain natriuretic pep-tide(BNP)in patients with acute left heart failure(AHF). Methods A total of 60 AHF patients were randomized into the observation group and the control group with each group 30. The patients in the two groups were given corre-sponding oxygen inhalation,bed rest,low-salt diet,furosemide,20 mg / time,1time / d,IVP;nitroglycerin(10 mg) +0. 9% sodium chloride(250mL),continuous pumping,1time / d;digoxin,0125mg / time,1time / d. On this basis,the patients in the observation group were given additional Shenfu injection(60 mL) + 0. 9% sodium chloride(250 mL),ivgtt,1time / d. Seven-day treatment was regarded as one course. Chemiluminescence immunoassay was used to detect the plasma BNP level before and after treatment. The echocardiography was used to determine LVEDD. LVEF was calculated. Guyatt was used for six minute walk test(6MWT). The maximum 6 min walking distance was deter-mined. Results BNP level after treatment was significantly reduced,and the reduced degree in the observation group was significantly superior to that in the control group(P < 0. 05). LVEDD after treatment was significantly decreased, but LVEF and 6MWT were significantly increased,those in the observation group were significantly superior to those in the control group(P < 0. 05). Conclusion Shenfu injection can enhance the left ventricular systolic function,effec-tively reduce the plasma BNP level,and improve the cardiac function with a satisfying effect.
Keywords:Shenfu injection  AHF  cardiac function  plasma BNP
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