幽门螺杆菌根除失败后两种补救方案疗效观察

目的观察含左旋氧氟沙星的雷贝拉唑与枸橼酸铋雷尼替丁（RBC，R）三联疗法补救幽门螺杆菌根除失败后的疗效及用药的安全性。方法入选86例患者均为初次治疗失败且停药4周以上，经胃镜和病理检查诊断为消化性溃疡和慢性萎缩性胃炎，快速尿素酶法检测证实为幽门螺杆菌感染，随机分为雷贝拉唑组（46例）和RBC组（40例）。雷贝拉唑组予以雷贝拉唑10mg，阿莫西林1000mg，左旋氧氟沙星200mg，口服，2次／d，连用10d；RBC组予以RBC350mg，阿莫西林1000mg，左旋氧氟沙星200mg，口服，2次／d，连用10d。补救结束4周后复查18C-尿素呼气实验，呼气试验阴性者为幽门螺杆菌补救根除成功，阳性为补救治疗失败。结果雷贝拉唑组补救根除率为76．2％，RBC组为73．0％，两组比较差异无统计学意义（P〉0．05）。两组均无严重不良反应。结论两种含左氧氟沙星补救方案对Hp根除率均较满意，用药不良反应率相当。

The Study of Two Kinds of Rescue Therapy after a Failed First-Line Triple Regimen Therapy

Objective To observe the efficacy and tolerbility of levofloxacin based triple regimen therapy after a failed first-line triple regimen therapy.Methods Eighty-six peptic ulcer or chronic atrophic gastritis patients with a previous failed course of first-line therapy were randomly divided into the group rabeprazole(46 cases) and the group ranitidine bismuth citrate(RBC,40 cases).The group rabeprazole were treated with rabepeazole 10 mg,levofloxacin 200 mg and amoxillin 1 000 mg po bid for 10 days,the group R...