Altered subcellular localization of IL-33 leads to non-resolving lethal inflammation |
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| Affiliation: | 1. F. Hoffmann-La Roche Ltd, pRED, Pharma Research and Early Development, Grenzacherstrasse 124, CH-4070 Basel, Switzerland;2. Stiefel, a GSK Company, Center for Skin Biology, 20 T.W. Alexander Dr., Research Triangle Park, NC 27709, USA;3. Hoffmann-La Roche Inc., pRED, Pharma Research and Early Development, Nutley, NJ, USA;1. Department of Oncology, The People’s Hospital of Linyi Economic and Technological Development Zone, Linyi 276000, China;2. Department of Radiotherapy, East Hospital, Tongji University School of Medicine, Shanghai 200120, China;1. Division of Allergic Diseases, Department of Internal Medicine, Mayo Clinic, Rochester, Minn;2. Department of Immunology, Mayo Clinic, Rochester, Minn;1. Department of Microbiology, School of Medicine, Qingdao University, Qingdao 266071, China;2. Department of Respiratory Medicine, East Hospital, Tongji University School of Medicine, Shanghai 200120, China;3. Department of Clinical Laboratory, Qingdao Municipal Hospital, Qingdao 266071, China;4. Department of Clinical Laboratory, Qingdao Women & Children Hospital, Qingdao 266034, China;5. Department of Pathology, East Hospital, Tongji University School of Medicine, Shanghai 200120, China;1. Departments of Dermatology at Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan;2. Departments of Biochemistry at Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan;3. Department of Allergy and Clinical Immunology, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo 157-8535, Japan;4. Laboratory of Systems Biology, Center for Experimental Medicine and Systems Biology, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan;1. Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China;2. Department of Clinical laboratory, The First Affiliated Hospital of Hainan Medical University, Haikou, Hainan, PR China;3. Department of Laboratory Medicine, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, PR China;4. Key Laboratory of Organ Transplantation, Ministry of Education; NHC Key Laboratory of Organ Transplantation; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, Hubei, PR China;1. Respiratory Research Unit, Bispebjerg University Hospital, Copenhagen, Denmark;2. Telethon Kids Institute, The University of Western Australia, Perth, Australia;3. Division of Cardiovascular and Respiratory Sciences, School of Biomedical Sciences, University of Western Australia, Perth, Australia;4. Department of Respiratory, Inflammation and Autoimmunity, MedImmune Ltd, Granta Park, Great Abington, CB21 6GH, UK;5. Institute for Respiratory Health, University of Western Australia, Perth, Australia |
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| Abstract: | |
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| Keywords: | IL-33 Non-resolving inflammation Eosinophilia Knock-in mouse Nuclear alarmin Immune homeostasis AM" },{" #name" :" keyword" ," $" :{" id" :" kwrd0045" }," $$" :[{" #name" :" text" ," _" :" alveolar macrophages BM" },{" #name" :" keyword" ," $" :{" id" :" kwrd0055" }," $$" :[{" #name" :" text" ," _" :" bone marrow eos" },{" #name" :" keyword" ," $" :{" id" :" kwrd0065" }," $$" :[{" #name" :" text" ," _" :" eosinophils FCM" },{" #name" :" keyword" ," $" :{" id" :" kwrd0075" }," $$" :[{" #name" :" text" ," _" :" flow cytometry FRC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0085" }," $$" :[{" #name" :" text" ," _" :" fibroblastic reticular cell HEV" },{" #name" :" keyword" ," $" :{" id" :" kwrd0095" }," $$" :[{" #name" :" text" ," _" :" high endothelial venule IHC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0105" }," $$" :[{" #name" :" text" ," _" :" immunohistochemistry IL-33" },{" #name" :" keyword" ," $" :{" id" :" kwrd0115" }," $$" :[{" #name" :" text" ," _" :" interleukin-33 LN" },{" #name" :" keyword" ," $" :{" id" :" kwrd0125" }," $$" :[{" #name" :" text" ," _" :" lymph node mac" },{" #name" :" keyword" ," $" :{" id" :" kwrd0135" }," $$" :[{" #name" :" text" ," _" :" macrophage NeoR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0145" }," $$" :[{" #name" :" text" ," _" :" Neomycin selection cassette SCS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0155" }," $$" :[{" #name" :" text" ," _" :" subcapsular sinus WT" },{" #name" :" keyword" ," $" :{" id" :" kwrd0165" }," $$" :[{" #name" :" text" ," _" :" wild type |
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