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| 辽宁地区妇女宫颈癌与人类白细胞抗原DRB1—15等位基因的关系 | |
| 引用本文： | 杜洋,董玉贞,王慧敏,李剑平. 辽宁地区妇女宫颈癌与人类白细胞抗原DRB1—15等位基因的关系[J]. 中外妇儿健康, 2011, 0(6) |
| 作者姓名： | 杜洋 董玉贞 王慧敏 李剑平 |
| 作者单位： | 辽宁省妇婴医院妇产科;沈阳军区第二零二医院妇产科;辽宁省血液中心; |
| 摘 要： | 目的:探讨人类白细胞抗原-DRB1(human leukocyte antigen-DRB1,HLA-DRB1)等位基因多态性与辽宁地区宫颈癌发病的相关性。方法:;以聚合酶链反应-序列特异性引物(polymerase chain reaction-sequence specific primers,PCR-SSP)法检测辽宁地区43例宫颈癌患者HLA-DRB1等位基因,与58例宫颈细胞学正常妇女进行比较。结果:患者组与对照组相比,HLA-DRB1*15等位基因频率显著增加(P<0.05),其它等位基因频率在两组间的差异未发现有统计学意义。结论:HLA-DRB1*15等位基因是宫颈癌的易感基因,可能与辽宁地区妇女对宫颈癌的遗传易感性有关。 |
| 关 键 词： | 宫颈癌 人类白细胞抗原 等位基因多态性 聚合酶链反应—序列特异性引物 |
The relationship between human leukocyte antigen(HLA)-DRB1*15 allele and cervical cancer in Liaoning province women |
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| DU Yang,DONG Yu-zhen,WANG Hui-min,LI Jian-ping. The relationship between human leukocyte antigen(HLA)-DRB1*15 allele and cervical cancer in Liaoning province women[J]. , 2011, 0(6) | |
| Authors: | DU Yang DONG Yu-zhen WANG Hui-min LI Jian-ping |
| Affiliation: | DU Yang1,DONG Yu-zhen2,WANG Hui-min2,LI Jian-ping3 |
| Abstract: | Objective:To investigate the relationship between the human leukocyte antigen(HLA)-DRB1 allele polymorphisms and cervical cancer in Liaoning province women.Methods:The HLA-DRB1 alleles were detected in 43 cervical cancer patients and 58 normal controls whom all from Liaoning province by using the polymerase chain reaction-sequence specific primers(PCR-SSP).The frequencies of HLA-DRB1 alleles were compared.Results:Compared with normal controls,the patients with cervical cancer had a significantly increased f... |
| Keywords: | Cervical cancer human leukocyte antigen allele polymorphism polymerase chain reaction-sequence specific primers |
| 本文献已被 CNKI 等数据库收录！ | |