| PCNA和p53蛋白作为原发性肝癌分子切缘界定指标的研究 |
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| 引用本文： | 吕宝军,谢小铭,曾庆安,苟新敏,王晓鸿. PCNA和p53蛋白作为原发性肝癌分子切缘界定指标的研究[J]. 中外妇儿健康, 2011, 0(6) |
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| 作者姓名： | 吕宝军 谢小铭 曾庆安 苟新敏 王晓鸿 |
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| 作者单位： | 中山大学附属第五医院普外II区;中山大学附属第五医院急诊科;中山大学附属第五医院病理科; |
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| 基金项目： | 珠海市科委项目(2009自筹) |
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| 摘 要： | 目的:通过分析PCNA和p53蛋白在癌组织和癌旁不同距离组织中的差异表达,探讨原发性肝癌手术切缘的分子边界。方法:应用免疫组织化学方法研究51例原发性肝癌和癌旁不同距离组织(距离肿瘤1、2、3cm)中PCNA和p53蛋白的表达情况。结果:PCNA和p53蛋白在原发性肝癌和癌旁不同距离组织中的表达呈现逐渐减弱的趋势,其递减表达差异具有统计学意义(P均<0.05)。结论:PCNA和p53蛋白在原发性肝癌和癌旁不同距离组织中趋势性差异表达,原发性肝癌手术切缘组织中存在分子边界。
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| 关 键 词： | 原发性肝癌 PCNA p53蛋白 分子切缘 |
Study on indicators of PCNA and p53 protein as resection margin of molecular in primary liver cancer |
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| LV Bao-jun,XIE Xiao-min,ZENG Qing-an,GOU Xin-min,WANG Xiao-hong. Study on indicators of PCNA and p53 protein as resection margin of molecular in primary liver cancer[J]. , 2011, 0(6) |
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| Authors: | LV Bao-jun XIE Xiao-min ZENG Qing-an GOU Xin-min WANG Xiao-hong |
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| Affiliation: | LV Bao-jun1,XIE Xiao-min2,ZENG Qing-an1,GOU Xin-min3,WANG Xiao-hong3 |
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| Abstract: | Objective:To investigate molecular boundary of surgical margin in primary liver cancer through the analysis of differential expression of PCNA and p53 protein in cancer tissue and adjacent tissues of different distances.Methods:PCNA and p53 protein expressions of 51 primary liver cancer and adjacent tissues at different distances(from the tumor 1,2,3 cm) were studied by immunohistochemistry.Results:PCNA and p53 protein expressions of primary liver cancer and adjacent tissues at different distances showed a ... |
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| Keywords: | Primary liver cancer PCNA p53 protein Resection margin of molecular |
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