症状性颅内动脉粥样硬化性狭窄的Wingspan支架成形术

目的 评价Gateway-Wingspan球囊支架系统治疗症状性颅内动脉粥样硬化性狭窄的安全性、可行性及近期疗效.方法 应用Gateway-Wingspan球囊支架系统治疗17例症状性颅内动脉狭窄患者,观察支架置入前后症状、狭窄率改善、手术成功率及并发症发生情况,术后平均随访5个月.结果 17处病变,其中位于颈内动脉颅内段5处,大脑中动脉5处,椎动脉颅内段4处,基底动脉3处.16处病变经Gateway球囊预扩张后支架成功准确释放.1例因Gateway球囊无法到达靶病变,支架直接定位后释放.支架成功率100%.治疗前平均狭窄率为82%,治疗后残余平均狭窄率为43%.术后平均随访5个月,4例一过性缺血发作(TIA)患者未再次发作;12例卒中患者症状均有明显改善.1例发生并发症,考虑为对侧半球梗死.未发生出血性并发症.结论 采用Gateway-Wingspan球囊支架系统治疗颅内动脉粥样硬化性狭窄有良好的安全性与短期疗效.

Treatment of symptomatic intracranial atheromatous ischemic disease with Wingspan stent system: short-term results

Objective To assess the safety, feasibility and short-term efficiency of the Wingspan stent system and Gateway balloon catheter in the treatment of symptomatic intracranial atheromatous stenosis. Methods Seventeen patients with symptomatic intracranial atheromatous stenosis were treated with the Gateway ballon-Wingspan system. The pre-and post-treatment improvement in symptom, severity of stenosis, successful rate of treatment, all kinds of complication were closely observed and compared before and after the procedure. Physician-reported follow-up in all 17 patients lasted for an average of 5 months. Results All 17 lesions showed involvement of the internal carotid artery (n = 5), middle cerebral arteries(n = 5), intracranial segmental vertebral artery(n = 4), basilar artery(n = 3). 16 lesions were successfully pre-dilated with an Gateway balloon catheter before the deployment of the self-expanding Wingspan stent.1 case failed because of the failure of delivery of the Gateway balloon catheter to the accurate site, but the stent was successfully deployed through direct localization. The successful rate of stenting was 100%. The Mean SD pretreatment stenosis was 82% and improved to 43% after stenting. During the follow-up(an average of 5 months), 4 patients with transient ischemic attack(TIA)but without recurrence, the other 12 patients with stroke showed significantly syptomatic improvements. One complication occured with attribution of contralateral hemisphere embolic infarction. There was no hemorrhagic complication. Conclusions Angioplasty and stenting with the Gateway-Wingspan stent system are safe and good in short-term outcomes for treating symptomatic intracranial arterial atheroscleromatic stenosis.