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Lack of association between genetic variants in the mannose-binding lectin 2 (MBL2) gene and HPV infection |
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| Authors: | Paola Parrella Davide Seripa Maria G. Matera Monica Rinaldi Emanuela Signori Carolina Gravina Antonietta P. Gallo Maria Prencipe Elvira Grandone Luciano Mariani Paola Cordiali Aldo Di Carlo Patrizia Stentella Antonio Pachì Vito M. Fazio |
| Affiliation: | (1) Laboratory of Oncology, Department of Research, IRCCS “Casa Sollievo della Sofferenza”, Viale Padre Pio, San Giovanni Rotondo, FG, I-71013, Italy;(2) Laboratory of Gerontology & Geriatrics, Department of Research, IRCCS “Casa Sollievo della Sofferenza”, San Giovanni Rotondo, FG, Italy;(3) Institute of Neurobiology and Molecular Medicine, CNR-ARTOV, Rome, Italy;(4) Laboratory of Molecular Medicine and Biotechnology, Campus Bio-Medico University School of Medicine, Rome, Italy;(5) Laboratory of Atherosclerosis and Thrombosis, Department of Research, IRCCS “Casa Sollievo della Sofferenza”, San Giovanni Rotondo, FG, Italy;(6) Department of Ginecology-Oncology, “Regina Elena” National Cancer Institute, Rome, Italy;(7) Laboratory of Clinical Pathology, “San Gallicano” Dermatology Institute, Rome, Italy;(8) IRCCS IFO, “San Gallicano” Dermatology Institute, Rome, Italy;(9) II Clinic of Obstetrics and Gynecology, University “La Sapienza”, Rome, Italy |
| Abstract: | Genetic variants in the immunomodulatory gene mannose-binding lectin 2 (MBL2), were associated with risk, severity, and frequency of viral infections. In a case-control setting, we investigated the association of MBL2 functional polymorphisms with Human Papillomas Virus (HPV) infection. No differences between cases (HPV+) and controls (HPV–) were found in the distribution of each single genotypes or allele. Haplotype analysis did not show any difference between HPV+ and HPV– groups. Paola Parrella and Davide Seripa contribute equally to this work. |
| Keywords: | Genetic variants Gynecological cancer/cervical Host– virus interaction HPV MBL2 |
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