CDK8在宫颈癌及宫颈上皮内瘤变中的表达及意义

目的：初步探讨CDK8在宫颈癌及宫颈上皮内瘤变（ cervical intraepithelial neoplasia ，CIN）中的表达及意义。方法免疫组化法检测宫颈癌、CIN组织及正常宫颈组织中CDK8的表达水平，分析CDK8表达与宫颈癌病理特征，以及宫颈上皮内瘤变临床转归的关系。结果 CDK8表达水平：宫颈癌组＞高度宫颈病变组＞低度宫颈病变组＞正常组，组间差异均有统计学意义（P＜0．05）；宫颈癌组淋巴结转移者CDK8的表达高于无转移者，CIN中高度宫颈病变者持续组CDK8表达高于痊愈组，差异均有统计学意义（ P＜0．05）。结论 CDK8高表达可能与宫颈癌进展相关，CDK8检测有助于预测宫颈病变转归。

Expression of CDK8 in cervical cancer and cervical intraepithelial neoplasia and its implication

Objective To investigate the expression of CDK 8 in cervical cancer and cervical intraepithelial neoplasia ( CIN) and its medical implication .Method The expression of CDK 8 in cervical carcinoma , cervical intraepithelial neoplasia and normal cervical tissue was detected by immunohistochemistry .The correlation between CDK 8 expression and pathological characteristics of cervical cancer , and clinical prognosis of cervical intraepithelial neoplasia were analyzed .Finding The levels of CDK8 expression of the groups of subjects are as such: that of the cervical cancer group >the high cervical lesions group >the low grade cervical lesions group >the normal group .The differences were statistically significant ( P<0.05).The level of expression of CDK8 of cervical cancer patients with metastasis in lymph nodes was higher than that of those without lymph node metastasis .The level of expression in patients with cervical intraepithelial neoplasia was higher than that of patients cured of high grade cervical lesions .The difference was significant ( P<0.05).Conclusion High level of expression of CDK 8 may be associated with the development of cervical cancer and the prognosis of cervical lesions can be predicted by CDK 8 expression .