TACE联合三维适形放疗治疗中晚期原发性肝癌疗效观察

目的探讨肝动脉灌注栓塞化疗（TACE）联合三维适形放疗（3-DCRT）治疗中晚期原发性肝癌的疗效。方法 87例患者随机分为TACE联合3-DCRT治疗组45例和TACE治疗组42例。联合组先进行TACE治疗1～2次,4～6周后行3-DCRT,分割剂量2.6～3.2 Gy,总剂量为48～60 Gy。TACE组行TACE治疗2～3次。结果联合组近期总有效率为86.7%,TACE组为66.7%（P〈0.05）;两组1年、2年、3年生存率分别为73.3%、53.3%、35.6%和59.5%、31.0%、14.3%,其中2、3年生存率差异具有统计学意义（P〈0.05）。结论 TACE联合3-DCRT治疗中晚期原发性肝癌具有较好的疗效,不良反应少。

Clinical observation of the effect of TACE combined with three dimensional conformal radiotherapy on patients with advanced hepatocellular carcinoma

Objective To investigate the clinical effects of transcatheter arterial chemoembolization（TACE） combined with three dimensional conformal radiotherapy（3-DCRT）on patients with advanced hepatocellular carcinoma.Methods A total of 87 patients with advanced hepatocellular carcinoma were randomly divided into TACE/3-DCRT group（n=45）and TACE group（n=42）.The patients in TACE/3-DCRT group were treated first with TACE and then 3-DCRT,the dose was 2.6～3.2Gy each time,and the total dose was 48～60Gy.The patients in TACE group were given TACE only.Results The total response（CR＋PR） were 86.7% in TACE/3-DCRT group,much higher than 66.7% in TACE group（P0.05）;The 1,2,3-year survival rates were 73.3%,53.3%,35.6% and 59.5%,31.0%,14.3%,respectively in the two groups.Conclusions TACE combined with 3-DCRT is more effective than TACE only,and the side effects are tolerated.