Bone mineral content of the radius: Good correlations with physicochemical determinations in iliac crest trabecular bone of normal and osteoporotic subjects

Specific gravity, porosity index (physical parameters), hydroxyproline, calcium, magnesium, and phosphorus (chemical parameters) were determined in iliac crest trabecular bone of normal and osteoporotic subjects. These physical and chemical parameters were compared to bone mineral content (BMC) measurements by x-ray photodensitometry of the radius. BMC values correlated negatively with porosity index, specific gravity, and degree of mineralization of trabecular bone matrix, which all increase with osteoporosis. There was a negative correlation between calcium and magnesium contents per net bone volume. “Distal” scans of the radius reflected better the axial skeleton mass than “proximal” scans, and physicochemical data correlated better with bone mineral content values than with bone mineral mass (BMM) values.