希森美康XN血液分析仪淋巴细胞结构参数在IM与B-CLPD鉴别诊断中的临床意义

目的研究希森美康XN血液分析仪淋巴细胞结构参数在传染性单核细胞增多症(IM)与B细胞慢性淋巴增殖性疾病(B-CLPD)鉴别诊断中的临床意义。方法回顾性分析2017年12月至2019年3月于上海长海医院门诊就诊的淋巴细胞增多患者(343例)希森美康XN血液分析仪淋巴细胞结构参数结果,并依据诊断分为IM组(111例),B-CLPD组(87例)与非肿瘤性增殖组(145例),通过受试者工作曲线(ROC曲线)与Logistic回归分析对淋巴细胞结构参数在IM组与B-CLPD组鉴别诊断中的价值进行评估。结果通过Logistic回归生成联合诊断因子pre1,当pre1临界值为0.5945时,pre1鉴别诊断IM与B-CLPD的灵敏度为91.9%,特异度为96.6%。结论希森美康XN血液分析仪淋巴细胞结构参数在鉴别诊断IM与B-CLPD中有较高的价值。

Clinical significance of lymphocyte structure parameters of Sysmex XN hematology analyzer in the differential diagnosis of infectious mononucleosis and B cell chronic lymphoproliferative disease

Objective To investigate the clinical significance of lymphocyte structure parameters of Sysmex XN hematology analyzer in the differential diagnosis of infectious mononucleosis(IM)and B cell chronic lymphoproliferative disease(B-CLPD).Methods Totally 343 patients with lymphocytosis admitted to Shanghai Changhai Hospital from December 2017 to March 2019 were retrospectively enrolled.Lymphocyte structure parameters of the patients were detected by Sysmex XN hematology analyzer.By the diagnosis of patients the samples were devided to 3 groups:IM group,B cell chronic lymphoproliferative disease group and non-neoplastic lymphocytosis group.Evaluated the value of lymphocyte structure parameters in the differential diagnosis of IM group and B-CLPD group by ROC curve and Logistic regression analysis.Results The combined diagnosis factors pre1 was formulated by Logistic regression analysis.When the cut-off value of pre1 was 0.5945,the sensitivity and specificity in the differential diagnosis of IM and B-CLPD was 91.9%and 96.6%.Conclusion Lymphocyte structure parameters of Sysmex XN hematology analyzer has a great value in the differential diagnosis of IM and B-CLPD.