| 代谢酶在嗜铬细胞瘤/副神经节瘤发病机制中的研究进展 |
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| 作者单位： | 四川大学华西医院实验医学科 |
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| 基金项目： | 四川省卫生健康委员会普及应用类项目(17PJ514)。 |
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| 摘 要： | 嗜铬细胞瘤/副神经节瘤(PPGL)为临床上少见的儿茶酚胺内分泌肿瘤,大多数为良性,有10%~25%为恶性并转移。三羧酸循环为能量供应的途径之一,当循环中任何酶突变会引起代谢改变,促进细胞增殖与存活,与肿瘤的发生发展、侵袭和转移相关。代谢酶相关突变参与PPGL发病机制,可成为PPGL靶向治疗的方向。
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| 关 键 词： | 嗜铬细胞瘤 副神经节瘤 靶向治疗 发病机制 |
Advances of metabolic enzymes in the pathogenesis of pheochromocytoma and paraganglioma |
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| Affiliation: | (Department of Laboratory Medicine,West China Hospital of Sichuan University,Chengdu,Sichuan 610041,China) |
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| Abstract: | Pheochromocytoma/paraganglioma(PPGL)is a clinically rare endocrine tumor secreting catecholamines.Most are benign,but 10%-25%are malignant and can metastasize.Tricarboxylic acid cycle is one of the pathways of energy supply.Any enzymes mutate in the cycle,metabolism will be changed,thereby promoting cell proliferation,which is related to the development,invasion and metastasis of tumors.Mutations of metabolic enzyme participate in the pathogenesis of PPGL and provide a possible direction for targeted therapy of PPGL. |
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| Keywords: | pheochromocytoma paraganglioma targeted therapy pathogenesis |
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