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| Intravesical Instillation in Pure Line LEW Rats and Nude Mice | |
| 引用本文： | 周洁,谢蜀生,郭晓云,莫曾南. Intravesical Instillation in Pure Line LEW Rats and Nude Mice[J]. 华中科技大学学报(医学英德文版), 2007, 27(3): 288-290. DOI: 10.1007/s11596-007-0318-4 |
| 作者姓名： | 周洁 谢蜀生 郭晓云 莫曾南 |
| 作者单位： | Department of Urology the First Affiliated Hospital of Guangxi Medical University，The Laboratory of Immunopharmacology Health Science Center Peking University，Department of Gastroenterology the First Affiliated Hospital of Guangxi Medical University，Department of Urology 3Department of Gastroenterology the First Affiliated Hospital of Guangxi Medical University，Nanning 530021 China，Beijing 100081 China，Nanning 530021 China，Nanning 530021 China |
| 摘 要： | In order to study bladder intravesical instillation methods in pure line LEW rats and nude mice, female LEW rats and nude mice aged 2 to 4 weeks were sacrificed. Their urethra and bladder were observed under anatomical microscopy. A trochar was prepared according to the outline and an- gle of the urethra. Ink was poured into female rats and nude mice bladder though urethra. Filling and staining of bladder were observed and evaluated under anatomical microscopy. Status and urethral injury of rats and mice were observed. The results showed that urethra anatomic structure of rats and nude mice was different from that of human urethra. When bladder was filled with ink and became blue, liquid was not seen to leak out. The success rate of intubation was high (100%). Living activi- ties of animals weren’t influenced by intravesical instillation. It was concluded that bladder irrigation might be a kind of valid and utilizable method in pure line rat and nude mouse empirical study. The model may be a more effective tool for study of bladder tumor. |
| 收稿时间： | 2006-12-20 |
Intravesical instillation in pure line LEW rats and nude mice |
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| Zhou Jie,Xie Shusheng,Guo Xiaoyun,Mo Zengnan. Intravesical instillation in pure line LEW rats and nude mice[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2007, 27(3): 288-290. DOI: 10.1007/s11596-007-0318-4 | |
| Authors: | Zhou Jie Xie Shusheng Guo Xiaoyun Mo Zengnan |
| Affiliation: | 1. Department of Urology, the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China 2. The Laboratory of Immunopharmacology, Health Science Center, Peking University, Beijing 100081, China 3. Department of Gastroenterology,the First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China |
| Abstract: | Summary In order to study bladder intravesical instillation methods in pure line LEW rats and nude mice, female LEW rats and nude mice aged 2 to 4 weeks were sacrificed. Their urethra and bladder were observed under anatomical microscopy. A trochar was prepared according to the outline and angle of the urethra. Ink was poured into female rats and nude mice bladder though urethra. Filling and staining of bladder were observed and evaluated under anatomical microscopy. Status and methral injury of rats and mice were observed. The results showed that urethra anatomic structure of rats and nude mice was different from that of human urethra. When bladder was filled with ink and became blue, liquid was not seen to leak out. The success rate of intubation was high (100%). Living activities of animals weren’t influenced by intravesical instillation. It was concluded that bladder irrigation might be a kind of valid and utilizable method in pure line rat and nude mouse empirical study. The model may be a more effective tool for study of bladder tumor. ZHOU Jie, make, born in 1975, M. D., Ph. D. This project was supported by a grant from National Youth Natural Sciences Foundation of China (No. 30200284). |
| Keywords: | intravesical instillation bladder neoplasms animal model nude mouse |
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