角膜碱烧伤的免疫学机制研究进展

角膜碱烧伤是眼科临床常见的致盲性眼病,一旦发生,治疗相当棘手,预后极差,其损伤机制的研究一直受到众多学者的重视。许多研究表明,角膜碱烧伤后免疫系统的参与起着非常重要的作用。角膜碱烧伤后角膜免疫微环境的变化致使各种效应细胞和炎性细胞出现规律性变化,另外各种炎性因子也参与角膜碱烧伤的病理损伤过程。就角膜碱烧伤的免疫学机制进行综述。

Research advance in immunological mechanism after corneal alkali burns

Corneal alkali burn is a common causing-blindness eye disease in clinic.The management of corneal alkali burn is very difficult and the treating outcome is often unsatisfied.The damage mechanisms of eye tissue after corneal alkali burn is concerned by many ophthalmologist.Many studies have shown that the involvement of the immune system plays a very important role in corneal alkali burn.The microenvironment change of immunology,variation law of effector cell and the effect of inflammatory cells following corneal alkali burn are reviewed to discuss the immunological mechanisms in corneal alkali burn.In addition,various inflammatory factors after corneal alkali burns are involved in the pathological damage process.The immunological mechanism of corneal damage after alkali burns was reviewed.