聚山梨酯80对呋麻滴鼻液稳定性的影响

目的：考察超声条件下不同浓度聚山梨酯80对呋麻滴鼻液（复方呋喃西林滴鼻液）的增溶作用，筛选聚山梨酯80的最佳用量，提高呋麻滴鼻液的稳定性。方法：用超声振荡仪将呋喃西林进一步粉碎成更细小的微粒，加入聚山梨酯80做增溶剂制备呋麻滴鼻液，样品置2～8℃的低温环境中冷贮3个月观察稳定性。结果：加入0．5％聚山梨酯80制备的呋麻滴鼻液析出结晶少于对照品；加入1．0％与2％聚山梨酯80制备的呋麻滴鼻液无结晶析出，含量符合规定。结论：聚山梨酯80能增加呋喃西林的溶解度，用于呋麻滴鼻液的制备能提高制剂稳定性。

Influence of Cpolysorbate 80 on Stability of Fuma Nasal Drops

Objective ： To study the solubilization role of Cpolysorbae80 on Fuma nasal drops under ultrasonic condition, and select the optimal dosage of Cpolysorbate80 to improve the stability of Fuma nasal drops. Method： Nitrofurazone was crushed into small particles under ultrasound conditions, and plus was as solvents in Fuma nasal drops. The stability of the solution was studied by deposit it at 2-8 ℃ for three months. Result： The crystal of Fuma nasal drops with 0.5% Cpolysorbate80 was less than that of reference, there was no crystal in Fuma nasal drops with 1.0% and 2.0% Cpolysorbate80, and the content accord with the standard. Conclusion： Cpolysorbate80 can improve the stability of Fuma nasal drops,it can be used as solubilization of the solution.