红景天注射液对麻醉犬心脏血流动力学及心肌耗氧量的影响

目的:研究红景天注射液治疗冠心病的药理作用及作用机制。方法:将实验犬20只,随机分为空白对照组、阳性药对照组和红景天注射液小、大剂量组。经戊巴比妥钠30mg·kg^-1静脉麻醉后开胸,分别测定冠脉血流量、心输出量、左室内压、左室内压上升最大速率(dp/dt_max)、冠状静脉窦血氧含量、动脉血氧含量、心肌耗氧量、心搏出量、耗氧指数、心脏指数、冠脉阻力、总外周阻力及氧利用率等。结果:动物静脉注射红景天注射液后,冠脉阻力、动脉血压、总外周阻力、耗氧指数、心肌耗氧量、心率明显降低,心输出量、心搏出量及冠状静脉窦血氧含量明显上升,与药前及空白对照组比较均有显著性差异(P<0.05-0.01);左室内压和心肌收缩力则无明显改变。结论:结果表明,用红景天注射液可扩张冠脉血管、降低心脏后负荷,在不明显增加心肌收缩力和左心室压力的情况下,心输出量和每博出量明显增加,心脏有效作功得到加强;还能使冠状静脉窦血氧含量显著增加,心肌耗氧指数降低,心肌耗氧量下降,从而改善心肌的供血供氧,调整心脏血管的顺应性,对心血管系统起到调整和改善作用。这可能是红景天注射液治疗冠心病的药理机理。

The effect of Hongjingtian (Gadol) injection on cardiac hemodynamics and myocardial oxygen consumption of dogs

Objective: To study the effect of Hongjingtian (Gadol) injection on cardiac hemodynamics and myocardial oxygen consumption for analyzing its underlying mechanism in the treatment of coronary heart disease. Method: A total of 20 dogs anesthetized with pen-tobarbital sodium (30 mg·kg^-1,i.v.) were evenly randomized into control group, low-dose Gadol (LDG) group, high-dose Gadol (HDG) group and Herbesser Injection group. The blood flow volume (BFV) of the left coronary artery and cardiac output (CO), left ventricular pressure (LVP), maximum ascending rate dp/dt_max) of LVP, mean arterial pressure (MAP) of the femoral artery,oxygen contents of the coronary artery and coronary vein (venous sinus) , oxygen consumption index (OCI), cardiac index (CI) , coronary artery resistance (CAR) and total peripheral resistance (TPR) as well as oxygen utilization rate (OUR) were detected respectively. Result: After venous injection of Gadol, CAR, MAP, TPR, OCI, myocardial oxygen consumption and heart rate lowered significantly (P< 0.05-0.01), while BFV and blood oxygen content of the venous sinus increased considerably (P< 0.05-0.01) in comparison with pre- injection. No significant differences were found in LVP and myocardial contractivity between control group and LDG, and between control and HDG groups respectively, conclusion: It showed dilation of the coronary artery and reduction of the cardiac afterload after injection of Gadol. Besides, CO and stroke volume increased considerably and the cardiac effective work was raised without any significantly simultaneous increase of both myocardial contractility and LVP. A decrease in the myocardial oxygen consumption and reduction of OCI indicates an improvement of the oxygen supply of the myocardium, and a favorable regulation of the compliance of the cardiac vessels. As a result, the cardiovascular perfonnance was ameh'orated. The abovementioned improvement of these indexes may contribute to the therapeutic effect of Gadol in the treatment of coronary heart disease in clinic.