256例药物性肝病血清酶谱学变化特点及预后分析

目的探讨药物性肝损伤的病因及临床特点，以提高临床医师对该病的认识。方法对1998～2007年本院药物性肝损伤病例256例进行回顾性研究其所用药物、临床表现和转归等特点。结果引起肝损伤药物中中药占首位（23．8％），其次为免疫抑制剂（11．7％）；临床表现主要为乏力、纳差、尿黄、恶心和右上腹不适等；治疗后88％治愈好转，病死率为6．6％。结论致肝损伤的药物种类繁多，临床表现无特异性，但病死率较高，临床医师用药时应注意监测肝功能。

Change Feature of Blood Serum Zymogram and Prognostic Analysis of 256 Cases of Drug-induced Liver Injury

Objective To analyze the etiology and clinical features of drug-induced liver damage,in order to draw more attention to this problem. Methods Two hundred and fifty-six cases over a 10-year period were retrospectively analyzed. Results A variety of drugs,in-cluding traditional Chinese medicines(23.8% of our total cases)and immunosuppressive agent(11.7%)caused liver damage. The main clinical manifestations of it were fatigue,nausea,vomiting and jaundice. In 78.5% of our cases,the symptoms were relieved or completely disappeared, but there was still 6.6% mortality rate. Conclusion The clinical features of drug-induced liver damage are of no specificity,and the mortality of it is high. Liver function should he monitored when suspected are prescribed.