| 抑郁症患者血小板蛋白激酶C水平的变化 |
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| 引用本文： | 许晶,马丽珍,王俊平. 抑郁症患者血小板蛋白激酶C水平的变化[J]. 临床精神医学杂志, 2003, 13(5): 258-259 |
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| 作者姓名： | 许晶 马丽珍 王俊平 |
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| 作者单位： | 116011,大连医科大学第一临床学院神经内科;116011,大连医科大学第一临床学院神经内科;116011,大连医科大学第一临床学院神经内科 |
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| 基金项目： | 辽宁省科委课题基金资助 (批准文号 0 0 2 0 63 ) |
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| 摘 要： | 目的：探讨抑郁症患者血小板细胞浆和细胞膜蛋白激酶C(PKC)的变化及其意义。方法：采用[^3H]12,13-二丁酰佛波醇酯(PDBu)结合法,测定23例抑郁症患者和10名正常对照者的血小板细胞浆和细胞膜PKC水平。结果：与正常对照组比较,抑郁症组血小板胞膜PKC水平显著降低,血小板胞浆PKC水平差异无显著性。结论：蛋白激酶C的改变在抑郁症发病机制中可能起一定作用。
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| 关 键 词： | 抑郁症 血小板 蛋白激酶C |
| 文章编号： | 1005-3220(2003)05-0258-02 |
| 修稿时间： | 2003-03-27 |
Levels of protein kinase C in platelets of depressed patients |
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| Xu Jing,Ma Lizhen,Wang Junping. Levels of protein kinase C in platelets of depressed patients[J]. Journal of Clinical Psychological Medicine, 2003, 13(5): 258-259 |
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| Authors: | Xu Jing Ma Lizhen Wang Junping |
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| Affiliation: | Xu Jing,Ma Lizhen,Wang Junping.Department of Neurology,the First Clinical Hospital,Dalian Medical University,Dalian 116011 |
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| Abstract: | Objective:To investigate the level of protein kinase C (PKC) in platelets of depressed patients. Method:Protein kinase C was determined by using [ 3 H] phorbol dibutyrate(PDBu) as the radioligand in the cytosolic and membranal fractions of platelets in depressed patients and normal controls. Results:[ 3 H] PDBu binding ability with PKC in membranal fraction of depressed patients was significantly lower than that of the controls. There was no difference in [ 3 H] PDBu binding ability with PKC in cytosolic fraction between the two groups. Conclusion: Changes of protein kinase C may play a role in the etiology of depression. |
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| Keywords: | Depression Platelets Protein kinase C |
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