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| 生精细胞凋亡的分子机制研究 | |
| 引用本文： | 贾悦,王雪松,孙敏,崔毓桂. 生精细胞凋亡的分子机制研究[J]. 生殖医学杂志, 2007, 16(3): 213-216 |
| 作者姓名： | 贾悦 王雪松 孙敏 崔毓桂 |
| 作者单位： | 南京医科大学第一附属医院临床生殖医学中心,南京,210038 |
| 摘 要： | 生精过程中细胞凋亡过程对维持正常的精子生成至关重要,该过程的失衡是导致少精子无精子症的重要机制之一,已受到广泛关注。哺乳动物生精细胞凋亡过程中通过胱门蛋白酶的主要涉及三条途径,分别是与细胞色素C相关的内源性凋亡通路、涉及死亡受体及其配体的外源性通路和与内质网(ER)相关的第三条途径。本文就睾丸生精细胞凋亡的分子机制的研究情况作一综述,并提出生殖细胞凋亡机制存在的问题及研究前景。 |
| 关 键 词： | 睾丸 生精细胞 凋亡 分子机制 |
| 文章编号： | 1004-3845（2007）03-0213-04 |
| 修稿时间： | 2005-01-312007-02-28 |
The molecular mechanism involved in the apoptosis of sperm cell |
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| JIA Yue,WANG Xue-song,SUN Min,CUI Yu-gui. The molecular mechanism involved in the apoptosis of sperm cell[J]. Journal of Reproductive Medicine, 2007, 16(3): 213-216 | |
| Authors: | JIA Yue WANG Xue-song SUN Min CUI Yu-gui |
| Affiliation: | Clinical Center of Reproductive Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210038 |
| Abstract: | Apoptosis plays a pivotal role in the spermatogenesis.Disequilibrium of apoptosis in germ cells is one of the reasons for azoospermia.Three major pathways are involved in the process of caspase activation and apoptosis in mammalian cells.One is the intrinsic pathway for apoptosis induced by releasing the cytochrome C into the cytosol.The death receptor(Fas/FasL) has been involved in the second pathway,also known as the extrinsic pathway.Last pathway is related with the endoplamic reticulum.We reviewed the molecular mechanism involved in the apoptosis of sperm cell,and put forward the questions and perspective in this research field. |
| Keywords: | Testis Sperm cell Apoptosis Molecular mechanism |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |